...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Medical Genomics >Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case–control study
【24h】

Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case–control study

机译：Pick1和BDNF依赖性风险增加的挑选和BDNF变异：一个病例对照研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Genetic factors play an important role in susceptibility to methamphetamine dependency. In this line, protein that interact with C-kinase-1 (PICK1) and brain-derived neurotrophic factor (BDNF) genes are linked to methamphetamine dependence (substance use disorder). Thus, in a case–control study, we investigated the association between polymorphisms of PICK1 and BDNF genes and methamphetamine dependence in an Iranian population. Total of 235 cases and 204 controls were recruited in a period between 2015 to 2018. The PICK1-rs713729, -rs2076369 and BDNF-rs6265 genotypes were determined via ARMS-PCR assay. Statistical analysis was performed, using SPSS 20.0, PHASE 2.1.1 program as well as SNP Analyzer 2.0. In the present study, two polymorphisms including PICK1-rs713729 (OR 1.38 (CI 1.08–1.52; P-value 0.004) in multiplicative and dominant models, and PICK1-rs2076369 (OR 1.31 (CI 1.10–1.56; P-value 0.002) in multiplicative, dominant and co-dominant models were associated with the risk of methamphetamine abuse. Moreover, haplotype analysis showed a significant association of haplotype AG (OR 2.50 (CI 1.50–4.16; P-value 0.0002) in dominant, recessive and co-dominant models, and haplotype TT (OR 0.67 (CI 0.50–0.91; P-value 0.009) in dominant and co-dominant models with the risk of methamphetamine abuse. None of the polymorphisms in this study had a high level of linkage disequilibrium. Our findings indicate that the PICK1 gene polymorphism might affect the risk of methamphetamine dependency in our population.
机译：遗传因素在对甲基苯丙胺依赖性的易感性中发挥着重要作用。在该线中，与C-激酶-1（PICK1）和脑衍生的神经营养因子（BDNF）基因相互作用的蛋白质与甲基苯丙胺依赖性（物质使用障碍）连接。因此，在案例对照研究中，我们研究了伊朗人群的PICK1和BDNF基因的多态性与甲基苯丙胺依赖性之间的关联。在2015年至2018年期间，共招募了235例和204个控件。通过Arms-PCR测定确定Pick1-RS713729，-RS2076369和BDNF-RS6265基因型。使用SPSS 20.0，阶段2.1.1程序以及SNP分析器2.0进行统计分析。在本研究中，两个多态性，包括PICK1-RS713729（或1.38（CI 1.08-1.52; P值0.004），以及PICK1-RS2076369（或1.31（CI 1.10-1.56; P值0.002）乘法，优势和共同主导模型与甲基苯丙胺滥用的风险有关。此外，单倍型分析显示了单倍型Ag（或2.50（CI 1.50-4.16; P值0.0002）的显着关联，隐性和共同占主导地位模型，单倍型TT（或0.67（CI 0.50-0.91; p值0.009），具有甲基苯丙胺滥用风险的主导和共同主导模型。本研究中没有多态性具有高水平的连锁不平衡。我们的研究结果表明PICK1基因多态性可能影响人口甲基苯丙胺依赖性的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号