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首页> 外文期刊>BMC Medical Genomics >TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV children and adolescents in Uganda
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TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV children and adolescents in Uganda

机译：TERT RS2736100和TERC RS16847897基因型适中，内化精神障碍与乌干达艾滋病毒儿童和青少年的促进端子缺失之间的关联

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Internalizing mental disorders (IMDs) (depression, anxiety and post-traumatic stress disorder) have been associated with accelerated telomere length (TL) attrition; however, this association has not been investigated in the context of genetic variation that has been found to influence TL. We have previously reported an association between IMDs and accelerated TL attrition among Ugandan HIV children and adolescents. This study investigated the moderating effects of selected single nucleotide polymorphisms in the telomerase reverse transcriptase gene (TERT) (rs2736100, rs7726159, rs10069690 and rs2853669) and the telomerase RNA component gene (TERC) (rs12696304, rs16847897 and rs10936599) on the association between IMDs and TL, among Ugandan HIV children (aged 5–11?years) and adolescents (aged 12–17?years). We found no significant interaction between IMDs as a group and any of the selected SNPs on TL at baseline. We observed significant interactions of IMDs with TERT rs2736100 (p?=?0.007) and TERC rs16847897 (p?=?0.012), respectively, on TL at 12?months. TERT rs2736100 and TERC rs16847897 moderate the association between IMDs and TL among Ugandan HIV children and adolescents at 12?months. Understanding the nature of this association may shed light on the pathophysiological mechanisms underlying advanced cellular aging in IMDs.
机译：内化精神障碍（IMDS）（抑郁症，焦虑和创伤后应激障碍）已经与加速的端粒长度（TL）磨损有关;然而，在发现影响T1的遗传变异的背景下尚未研究这种关联。我们此前已在乌干达艾滋病毒儿童和青少年之间报告了IMDS之间的关联和加速TL TRITION。本研究研究了所选单核苷酸多态性在端粒酶逆转录酶基因（TERT）（RS2736100，RS7726159，RS10069690和RS2853669）中的调节效果（RS2736100，RS2853669）和IMDS之间的关联的端粒酶RNA组分基因（TRER12696304，RS10936599）和TL，乌干达艾滋病毒儿童（5-11岁？年龄）和青少年（12-17岁？年龄）。我们发现IMDS与基线TL上的任何所选SNP之间没有显着的相互作用。我们观察到IMDS与TERT RS2736100（P？= 0.007）和TL的显着相互作用，分别在12.个月的TL上（p？= 0.012）。 TERT RS2736100和TERC RS16847897中度乌干达艾滋病毒儿童和青少年之间的IMD和TL之间的关联在12？几个月。了解该协会的性质可能对IMDS中晚期细胞衰老的病理生理机制脱光。

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