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首页> 外文期刊>BMC Gastroenterology >A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study
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A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study

机译：阶段IB / IIA食管鳞状细胞癌分层的预后模型：回顾性研究

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To explore the postoperative prognosis of esophageal squamous cell carcinoma (ESCC) patients with stage IB/IIA, using a prognostic score (PS). Stage IB/IIA ESCC patients who underwent esophagectomy from 1999 to 2010 were included. We retrospectively recruited 153 patients and extracted their medical records. Moreover, we analyzed the programmed death ligand-1 (PD-L1) expression of their paraffin tissue. The cohort were randomly divided into a training group (N?=?123) and a validation group (N?=?30). We selected overall survival (OS) as observed endpoint. Prognostic factors with a multivariable two-sided P??0.05 met standard of covariate inclusion. Univariable and multivariable analyses identified pTNM stage, the number of lymph nodes (NLNs) and PD-L1 expression as independent OS predictors. Primary prognostic score which comprised above three covariates adversely related with OS in two cohorts. PS discrimination of OS was comparable between the training and internal validation cohorts (C-index?=?0.774 and 0.801, respectively). In addition, the PS system had an advantage over pTNM stage in the identification of high-risk patients (C-index?=?0.774 vs. C-index?=?0.570, P??0.001). Based on PS cutoff, training and validation datasets generated low-risk and high-risk groups with different OS. Our three-factor PS predicted OS (low-risk subgroup vs. high-risk subgroup 60-month OS, 74% vs. 23% for training cohort and 83% vs. 45% for validation cohort). Our study suggested a PS for significant clinical stratification of IB/IIA ESCC to screen out subgroups with poor prognosis.
机译：利用预后评分（PS）探讨食管鳞状细胞癌（ESCC）阶段IB / IIa患者的术后预后。包括1999年至2010年从1999年到2010年接受食管切除术的IB / IIA ESCC患者。我们回顾性地招募了153名患者并提取了他们的病历。此外，我们分析了它们的石蜡组织的编程死亡配体-1（PD-L1）表达。将群组随机分为训练组（N？=？123）和验证组（n？=？30）。我们选择了终端点的整体生存（OS）。具有多变量双面P的预后因素？＆？0.05符合协变量的标准。不可变化和多变量分析鉴定了PTNM阶段，淋巴结数（NLNS）和PD-L1表达式作为独立的OS预测器。三种协调因子组成的主要预后分数与两个群组中的OS不利有关。 PS对OS的歧视与培训和内部验证队列（C-INDEX？=？0.774和0.801分别）相当。此外，PS系统在高风险患者的鉴定中具有PTNM阶段的优势（C折射率？= 0.774与C折射率？=？0.570，P≤≤0.001）。基于PS截止，培训和验证数据集生成具有不同操作系统的低风险和高风险群体。我们的三个因素PS预测OS（低风险亚组与高风险亚组60个月OS，培训队列的74％与23％，验证队列的83％与45％）。我们的研究表明，对于IB / IIA ESCC的显着临床分层，以筛选出预后差的亚组。

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