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首页> 外文期刊>BMC Infectious Diseases >Surveillance of the major pathogenic arboviruses of public health concern in Gabon, Central Africa: increased risk of West Nile virus and dengue virus infections
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Surveillance of the major pathogenic arboviruses of public health concern in Gabon, Central Africa: increased risk of West Nile virus and dengue virus infections

机译：中非加蓬公共卫生关注的主要致病性遗传群体的监测：西尼罗河病毒和登革热病毒感染的风险增加

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Increasing arbovirus infections have been a global burden in recent decades. Many countries have experienced the periodic emergence of arbovirus diseases. However, information on the prevalence of arboviruses is largely unknown or infrequently updated because of the lack of surveillance studies, especially in Africa. A surveillance study was conducted in Gabon, Central Africa, on arboviruses, which are a major public health concern in Africa, including: West Nile virus (WNV), dengue virus (DENV), Zika virus (ZIKV), yellow fever virus (YFV), chikungunya virus (CHIKV), and Rift Valley fever virus (RVFV). Serological and molecular assays were performed to investigate past infection history and the current status of infection, using serum samples collected from healthy individuals and febrile patients, respectively. The overall seroprevalence during 2014?2017 was estimated to be 25.3% for WNV, 20.4% for DENV, 40.3% for ZIKV, 60.7% for YFV, 61.2% for CHIKV, and 14.3% for RVFV. No significant differences were found in the seroprevalence of any of the viruses between the male and female populations. However, a focus on the mean age in each arbovirus-seropositive individual showed a significantly younger age in WNV- and DENV-seropositive individuals than in CHIKV-seropositive individuals, indicating that WNV and DENV caused a relatively recent epidemic in the region, whereas CHIKV had actively circulated before. Of note, this indication was supported by the detection of both WNV and DENV genomes in serum samples collected from febrile patients after 2016. This study revealed the recent re-emergence of WNV and DENV in Gabon as well as the latest seroprevalence state of the major arboviruses, which indicated the different potential risks of virus infections and virus-specific circulation patterns. This information will be helpful for public health organizations and will enable a rapid response towards these arbovirus infections, thereby preventing future spread in the country.
机译：近几十年来，枝芽孢杆菌感染越来越多。许多国家经历了腹腔病毒疾病的周期性出现。然而，由于缺乏监测研究，特别是在非洲，有关腹膜病毒患病率的信息基本上是未知的或不经常更新。在中非的加蓬在阿芽病毒中进行了监测研究，这是非洲的主要公共卫生问题，包括：西尼罗河病毒（WNV），登革热病毒（Denv），Zika病毒（ZIKV），黄热病病毒（YFV ），Chikungunya病毒（Chikv）和Rift Valley发烧病毒（RVFV）。使用从健康个体和发热患者收集的血清样品进行血清学和分子测定以研究过去的感染历史和感染的当前状态。 2014年2017年的整体Seroprevalence估计为WNV的25.3％，丹佛的20.4％，ZIKV为40.3％，YFV的60.7％，CHIKV为61.2％，RVFV为14.3％。在雄性和女性群体之间的任何病毒的Seroprevaliences中没有发现显着差异。然而，对每种腹膜血清阳性个体的平均年龄的关注表明Wnv-血清阳性个体的年龄明显更年轻，表明Wnv和Denv在该地区引起了相对近期的流行病，而Chikv以前积极分发。值得注意的是，通过在2016年以前的患者收集的血清样本中检测到从发热患者收集的血清样品中的WNV和DENV基因组来支持该指示。该研究揭示了GABON的WNV和DENV的最近重新出现，以及最新的主要血清普促状态Arboviruses，表明病毒感染和特定病毒特异性循环模式的不同潜在风险。这些信息对公共卫生组织有所帮助，并将能够快速反应这些腹腔病毒感染，从而防止该国的未来蔓延。

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