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首页> 外文期刊>BMC Musculoskeletal Disorders >Prevalence and risk factors for bone loss in rheumatoid arthritis patients from South China: modeled by three methods
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Prevalence and risk factors for bone loss in rheumatoid arthritis patients from South China: modeled by three methods

机译：南华类风湿性关节炎骨质损失患病率和危险因素：三种方法建模

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To explore the prevalence of bone loss among patients with rheumatoid arthritis (RA) and healthy controls (HC) and further explored the risk factors for osteopenia and osteoporosis of RA patients. A cross-sectional survey was undertaken in four hospitals in different districts in South China to reveal the prevalence of bone loss in patients. Case records, laboratory tests, and bone mineral density (BMD) results of patients were collected. Traditional multivariable logistic regression analysis and two machine learning methods, including least absolute shrinkage selection operator (LASSO) and random forest (RF) were for exploring the risk factors for osteopenia or osteoporosis in RA patients. Four hundred five patients with RA and 198 HC were included. RA patients had lower BMD in almost BMD measurement sites than healthy controls; the decline of lumbar spine BMD was earlier than HC. RA patients were more likely to comorbid with osteopenia and osteoporosis (p for trend ?0.001) in the lumbar spine than HC. Higher serum 25-hydroxyvitamin D3 level and using tumor necrosis factor inhibitor in the last year were protective factors; aging, lower body mass index, and increased serum uric acid might be risk factors for bone loss. RA patients were more prone and earlier to have bone loss than HC. More attention should be paid to measuring BMD in RA patients aging with lower BMI or hyperuricemia. Besides, serum vitamin D and all three measurement sites are recommended to check routinely. TNFi usage in the last year might benefit bone mass.
机译：为了探讨类风湿性关节炎（RA）和健康对照（HC）患者骨质损失的患病率，并进一步探索了RA患者骨质增生和骨质疏松症的危险因素。南方不同地区的四家医院开展了一个横断面调查，揭示了患者骨质流失的患病率。收集患者的案例记录，实验室测试和骨矿物密度（BMD）结果。传统的多变量逻辑回归分析和两种机器学习方法，包括最不绝对的收缩选择运营商（套索）和随机森林（RF）用于探索RA患者骨质衰减或骨质疏松症的危险因素。包括四百五名RA和198 HC患者。 RA患者在几乎BMD测量部位较低的BMD比健康对照组;腰椎BMD的衰落早于HC。 RA患者更有可能在腰椎上与骨质增长和骨质疏松症（P用于趋势率为P. <0.001）。较高的血清25-羟基维生素D3水平并在去年使用肿瘤坏死因子抑制剂是保护因素;老化，降低体重指数和增加的血清尿酸可能是骨质损失的危险因素。 RA患者更容易发生，早些时候具有比HC的骨质损失。应更多地关注患者患者患者患者患者较低的BMI或heaturecicea患者。此外，建议血清维生素D和所有三个测量部位定期检查。去年的TNFI使用可能会使骨头群体受益。

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