...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Neuroscience >Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
【24h】

Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity

机译：神经反应性差异奖励和个人奖励和惩罚敏感性的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Men and women show differences in sensitivity to reward and punishment, which may impact behavior in health and disease. However, the neural bases of these sex differences remain under-investigated. Here, by combining functional magnetic resonance imaging (fMRI) and a variant of the Monetary Incentive Delay Task (MIDT), we examined sex differences in the neural responses to wins and losses and how individual reward and punishment sensitivity modulates these regional activities. Thirty-sex men and 27 women participated in the fMRI study. We assessed sensitivity to punishment (SP) and sensitivity to reward (SR) with the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ). In the MIDT, participants pressed a button to collect reward ($1, 1￠, or nil), with the reaction time window titrated across trials so participants achieved a success rate of approximately 67%. We processed the Imaging data with published routines and evaluated the results with a corrected threshold. Women showed higher SP score than men and men showed higher SR score than women. Men relative to women showed higher response to the receipt of dollar or cent reward in bilateral orbitofrontal and visual cortex. Men as compared to women also showed higher response to dollar loss in bilateral orbitofrontal cortex. Further, in whole-brain regressions, women relative to men demonstrated more significant modulation by SP in the neural responses to wins and larger wins, and the sex differences were confirmed by slope tests. Together, men showed higher SR and neural sensitivity to both wins, large or small, and losses than women. Individual differences in SP were associated with diminished neural responses to wins and larger wins in women only. These findings highlight how men and women may differ in reward-related brain activations in the MIDT and add to the imaging literature of sex differences in cognitive and affective functions.
机译：男女们表现出对奖励和惩罚的敏感性的差异，这可能会影响健康和疾病的行为。然而，这些性别差异的神经基础仍然被调查。这里，通过组合功能磁共振成像（FMRI）和货币激励延迟任务（MIDT）的变种，我们检查了神经响应的性别差异，以赢得和损失以及个人奖励和惩罚敏感性如何调查这些区域活动。三十性男性和27名女性参加了FMRI学习。我们评估了对惩罚（SP）的敏感性和奖励（SR）的敏感性，以惩罚和敏感性奖励调查问卷（SPSRQ）的敏感性。在中期，参与者按下按钮收集奖励（1,1¢或数量，1，1¢或数量），并在试验中滴定的反应时间窗口，因此参与者取得了约67％的成功率。我们使用已发布的例程处理了成像数据，并使用校正的阈值评估结果。妇女表现出高于男性和男性的SP分数比女性更高的SR得分。男性相对于女性的男性对双侧胰蛋白质和视觉皮层的收到美元或分奖励的回应率更高。与女性相比的男性也表现出对双侧胰蛋白酶体皮质的美元损失更高的反应。此外，在全脑回归中，妇女相对于男性在神经响应中展示了对胜利和更大胜利的神经响应中的更大调节，并且通过坡度测试证实了性差异。在一起，男性表现出更高的SR和胜利，大或小，损失的神经敏感性高于女性。 SP中的个体差异与胜利的神经响应减少，仅在女性中赢得胜利。这些调查结果突出了男女如何在较助的奖励相关的脑激活中不同，并加入认知和情感功能的性别差异的影像学文献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号