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首页> 外文期刊>BMC Pediatrics >Time to detection of anemia and its predictors among children living with HIV at Debre Tabor and University of Gondar Compressive Specialized Hospitals, 2020: a multicentre retrospective follow-up study
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Time to detection of anemia and its predictors among children living with HIV at Debre Tabor and University of Gondar Compressive Specialized Hospitals, 2020: a multicentre retrospective follow-up study

机译：在2020年德布鲁塔博尔和戈恩·塔博尔大学患有艾滋病毒的儿童贫血及其预测因子的时间，2020年：多中心回顾性随访研究

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Even though antiretroviral therapy access for HIV infected children increased dramatically, anemia have been continued as a challenge regardless of a cluster of differentiation (CD4) count and viral load. Hence, this study aimed to assess the time to detection of anemia and its predictors among children living with HIV at Debre Tabor and university of Gondar compressive specialized hospital, 2020. A retrospective follow-up study was conducted from January 2010 to December 2018. A total of 372 children under the age of 15 who had received ART were included in the study. Data were collected from children’s medical charts and ART registration logbook using a standard checklist. Besides, the data were entered into Epi data?4.2.2 and then exported to Stata 14.0 for further analysis. The Cox regression model, the variables having P-value ≤.05 with 95% CIs in multivariable analysis were declared as statistically significant for anemia. The mean (±SD) of follow-up periods were 56.6?±?1.7 SD months. The overall median survival time free from anemia was 137?months, and the incidence rate of anemia was 6.9 per 100 PYO (95% CI: 5.3, 7.8). Moreover, WHO clinical staging of III/IV [AHR: 4.2, 95% CI: 1.80, 11.1], low CD4 count below threshold [AHR: 1.9, 95% CI: 1.09, 3.37], cotrimoxazole preventive therapy non-users, and poor level of adherence [(AHR: 2.4, 95% CI: 1.20, 4.85] were the main predictors of the time to detection of anemia. The incidence rate of anemia in our retrospective cohort was high. The risk of anemia is present in children living with HIV infection but the risk for anemia is increased based on (WHO clinical staging III and IV, CD4 count below the threshold level, CPT non-users, and poor level of adherence). Since many of these risk factors are present routinely, even within one single patient, our clinical monitoring for anemia quarterly was fully justified as was our routine switch from standard therapies such as AZT to another regimen upon lab confirmation of anemia. Additional methods to improve cotrimoxazole preventative therapy and level of adherence are also needed.
机译：尽管艾滋病毒感染儿童的抗逆转录病毒治疗进入急剧增加，但贫血仍然是挑战，无论分化簇（CD4）计数和病毒载量如何。因此，本研究旨在评估在2020年1月至2018年1月至12月进行的回顾性后续研究，评估艾滋病毒艾滋病毒艾滋病毒儿童检测贫血及其预测因子的时间。a该研究中纳入了372名接受艺术的372名儿童。使用标准清单从儿童的医疗图表和艺术注册日志收集数据。此外，数据被输入到EPI数据？4.2.2然后导出到STATA 14.0以进行进一步分析。 Cox回归模型，具有95％的多变量分析中具有95％CIS的P值≤05的变量被宣布为贫血统计学意义。随访期的平均值（±SD）为56.6？±1.7 SD个月。无贫血的总体中位生存时间为137岁，贫血发病率为每100个斑疹6.9（95％CI：5.3,7.8）。此外，世卫组织III / IV的临床分期[AHR：4.2,95％CI：1.80,11.1]，低CD4计数低于阈值[AHR：1.9,95％CI：1.09,3.37]，Cotrimoxazole预防治疗非用户，以及遵守程度差[（ahr：2.4,95％ci：1.20,4.85]是检测贫血时的主要预测因子。我们的回顾性群体中贫血的发病率很高。贫血的风险存在于儿童中患有HIV感染，但基于（世卫组织临床分期III和IV，CD4计数低于阈值水平，CPT非用户和遵守水平较差）的血症的风险增加。由于许多这些风险因素是常规的，即使在一名患者中，我们对贫血季度的临床监测也是完全合理的，因为我们的常规切换是我们的常规切换，例如贫血实验室确认的另一种方案。还需要改善Cotrimoxazole预防治疗和依从性水平的方法。

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