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首页> 外文期刊>BMC Pregnancy and Childbirth >Changes in the cortisol and oxytocin levels of first-time pregnant women during interaction with an infant: a randomized controlled trial
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Changes in the cortisol and oxytocin levels of first-time pregnant women during interaction with an infant: a randomized controlled trial

机译：与婴幼儿的互动期间皮质醇和催产素水平的变化：随机对照试验

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Abstract Background During pregnancy, physiological, psychological, and social changes affect pregnant women’s childcare anxiety and childrearing behavior. However, there are scarce reports on hormonal evaluation related to such anxiety and behavior. Herein, we evaluated changes in salivary cortisol (primary outcome) and oxytocin (secondary outcome) levels of first-time pregnant women when interacting with an infant and discussed the relation of these changes to the women’s stress level. Methods This was a two-arm randomized controlled trial. Participants were randomly assigned using a web-based randomization system. The experimental group involved interaction with an infant for 30?min. The control group involved watching a DVD movie of an infant for 30?min. Saliva samples were collected at preintervention and postintervention. Saliva samples were assayed, and all data were compared between and within the groups using independent t-test and paired t-test with a two-sided 5% significance level. This study was approved by the Research Ethics Committee of St. Luke’s International University. Results A total of 102 women were randomly assigned to the experimental (n =?51) and control (n?=?51) groups. Finally, 38 women in the experimental group and 42 women in the control group were analyzed. The salivary cortisol level significantly decreased after the interventions in both groups (t?=?4.57, p ?=?0.00; t?=?5.01, p ?=?0.00). However, there were no significant differences in the salivary cortisol (t?=?0.349, p ?=?0.73) and oxytocin (t?=???1.945, p ?=?0.58) levels between the two groups. Conclusions The salivary cortisol level of first-time pregnant women significantly decreased in the experimental and control groups postintervention, although no significant difference was found between the two groups. Such decrease indicates stress reduction and release among these women. The absence of a significant increase in salivary oxytocin level in both groups may be related to the limitations of an insufficient number of samples that could be analyzed owing to the small saliva volume in some samples and the lack of adequate tactile stimulation of the intervention protocol. These results and procedural limitations provide useful insights into approaching subsequent studies aiming at continuously optimizing detection procedures. Trial registration UMIN000028471 (Clinical Trials Registry of University Hospital Information Network. July 31, 2017- Retrospectively registered.
机译：妊娠期间的抽象背景会影响孕妇的虐待妇女的虐待和儿童行为。但是，有关与这种焦虑和行为有关的荷尔蒙评估的稀缺报告。在此，我们在与婴儿互动时评估唾液皮质醇（初级结果）和催产素（次要结果）和催产素（次要结果）水平，并讨论了这些变化对妇女的压力水平的关系。方法这是双臂随机对照试验。使用基于Web的随机化系统随机分配参与者。实验组涉及与婴儿的相互作用30？min。控制组涉及观看婴儿的DVD电影30？分钟。在Preintervention和PostInctention收集唾液样品。测定唾液样品，并使用独立的T检验和与双面5％显着性水平的双面的T检验进行比较所有数据。本研究经批准了圣卢克国际大学研究伦理委员会。结果总共102名妇女随机分配给实验（n =Δ51）和控制（n？= 51）组。最后，分析了实验组中的38名女性和对照组中的42名女性。两组干预后的唾液皮质醇水平显着降低（t？= 4.57，p？= 0.00; t？=？5.01，p？= 0.00）。然而，唾液皮质醇中没有显着差异（T？= 0.349，p？=Δ0.73）和两组之间的催产素（t？= ??? 1.945，p？= 0.58）水平。结论实验和对照组初期孕妇的唾液皮质醇水平显着降低，但两组之间没有发现显着差异。这种减少表明这些妇女的压力降低和释放。在两组中没有唾液催产素水平的显着增加可能与由于一些样品中的小唾液体积和干预方案缺乏足够的触觉刺激而分析的样品数量不足的样品的局限性有关。这些结果和程序限制为接近旨在不断优化检测程序的后续研究提供了有用的见解。试验登记UMIN000028471（大学医院信息网络临床试验登记处。2017年7月31日 - 回顾性注册。

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