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Restorative reproductive medicine for infertility in two family medicine clinics in New England, an observational study

机译:一种恢复性生殖医学在新英格兰两家家庭医学诊所的不孕症,一个观察研究

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Restorative reproductive medicine (RRM) seeks to identify and correct underlying causes and factors contributing to infertility and reproductive dysfunction. Many components of RRM are highly suitable for primary care practice. We studied the outcomes amongst couples who received restorative reproductive medicine treatment for infertility in a primary care setting. Two family physicians in Massachusetts trained in a systematic approach to RRM (natural procreative technology, or NaProTechnology) treated couples with infertility. We retrospectively reviewed the characteristics, diagnoses, treatments, and outcomes for all couples treated during the years 1989 to 2014. We compared pregnancy and live birth by clinical characteristics using Kaplan-Meier analysis. We employed the Fleming-Harrington weighted Renyi test or the logrank test to compare the cumulative proportion with pregnancy or with live birth. Among 370 couples beginning treatment for infertility, the mean age was 34.8?years, the mean prior time trying to conceive was 2.7?years, and 27% had a prior live birth. The mean number of diagnoses per couple was 4.9. Treatment components included fertility tracking with the Creighton Model FertilityCare System (80%); medications to enhance cervical mucus production (81%), to stimulate ovulation (62%), or to support the luteal phase (75%); and referral to female laparoscopy by a surgeon specializing in endometriosis (46%). The cumulative live birth rate at 2?years was 29% overall; this was significantly higher for women under age 35 (34%), and for women with body mass index ?25 (40%). There were 2 sets of twins and no higher-order multiple gestations. Of the 63 births with data available, 58 (92%) occurred at term. Family physicians can provide a RRM approach for infertility to identify underlying causes and promote healthy term live births. Younger women and women with body mass index ?25 are more likely to have a live birth.
机译:恢复性生殖医学(RRM)寻求识别和纠正潜在的潜在原因和因素,导致不孕症和生殖功能障碍。 RRM的许多组件非常适合初级保健实践。我们研究了在初级保健环境中接受恢复性生殖医学治疗的夫妻中的夫妻中的结果。马萨诸塞州的两个家庭医生以系统的方式培训了RRM(自然生殖技术,或尼泊策)治疗夫妇的不孕症。我们回顾性地审查了1989年至2014年期间治疗的所有夫妻的特征,诊断,治疗和结果。我们使用Kaplan-Meier分析通过临床特征进行了妊娠和活产。我们雇用了弗莱明 - 哈灵顿加权仁义试验或Logrank检验,比较妊娠期累积或活产。在370对夫妻开始治疗的不孕症中,平均年龄为34.8?年龄,试图设想的平均年次是2.7?年龄,27%的人生出生。每对夫妇的平均诊断数量为4.9。治疗组件包括与Creighton Model FertcateCare系统(80%)的生育率跟踪;药物以增强宫颈粘液生产(81%),刺激排卵(62%),或支撑耐肺阶段(75%);并通过专门用于子宫内膜异位症的外科医生(46%)转诊女性腹腔镜检查。累积的活产率为2?年为29%; 35岁以下的女性(34%)和体重指数的妇女的妇女显着提高了这一点。有2套双胞胎,没有高阶多个妊娠。在可用数据的63个初生中,58(92%)发生任期。家庭医生可以为不孕症提供RRM方法,以确定潜在的原因和促进健康术语活产出生。体重指数的年轻女性和女性& 25更有可能生育。

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