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首页> 外文期刊>Cancer Communications >Exhaled breath diagnostics of lung and gastric cancers in China using nanosensors
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Exhaled breath diagnostics of lung and gastric cancers in China using nanosensors

机译：利用纳米传感器呼出中国肺和胃癌的呼气诊断

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Breath analysis is a promising diagnostic approach for various conditions [1, 2]. It is based on the identification of volatile organic compounds (VOCs) emitted in the breath, which creates a unique volatolomic signature [3]. Owing to their characteristics, VOCs can be measured non-intrusively from the breath or other body sources [3, 4]. Several studies have shown the diagnostic potential for a variety of conditions based on VOC analysis [5-9]. Malignant diseases, where early detection is crucial, are the main focus of VOC analysis, with lung cancer (LC) and gastric cancer (GC) being the most studied. LC and GC together were responsible for approximately 2.5 million deaths globally in 2018 [10]. The aim of VOC analysis of the breath using sensors is to identify a “VOC-print” comprising the total abundances and ratios of the compounds in the breath, giving an overall unique chemical pattern [11]. This technology can help to address specific challenges concerning LC screening and GC mortality [12,13]. To facilitate real-world applications, different ethnicand culture-based populations should be sampled. Here, we carried out a VOC-based clinical trial for GC and LC detection in China to classify these two major malignancies with different genetic and cultural backgrounds, using our developed sensors [1] with newly-developed sensor-printing and sampling methods.
机译：呼气分析是各种条件的有前途的诊断方法[1,2]。它基于呼吸中发出的挥发性有机化合物（VOC）的鉴定，这产生了独特的挥发性签名[3]。由于它们的特点，VOC可以从呼吸或其他体源进行非侵入[3,4]。几项研究显示了基于VOC分析的各种条件的诊断潜力[5-9]。早期检测至关重要的恶性疾病是VOC分析的主要重点，肺癌（LC）和胃癌（GC）是最受研究的。 LC和GC在一起负责2018年全球约有250万人死亡[10]。使用传感器的呼吸VOC分析的目的是识别包含呼吸中化合物的总丰度和比率的“VOC-PRINT”，给出了整体独特的化学模式[11]。该技术可以帮助解决关于LC筛选和GC死亡率的特定挑战[12,13]。为促进现实世界的应用，应抽样不同的基于族人文化的人群。在这里，我们在中国进行了基于VC和LC检测的VC基础临床试验，以通过新开发的传感器印刷和采样方法使用我们发达的传感器[1]对这些两个主要的恶性肿瘤进行分类。

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