...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alzheimer s Research & Therapy >Characterization of symptoms and determinants of disease burden in dementia with Lewy bodies: DEvELOP design and baseline results
【24h】

Characterization of symptoms and determinants of disease burden in dementia with Lewy bodies: DEvELOP design and baseline results

机译：用石油体痴呆症疾病负担症状和决定因素的特征：开发设计和基线结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The DEmEntia with LEwy bOdies Project (DEvELOP) aims to phenotype patients with dementia with Lewy bodies (DLB) and study the symptoms and biomarkers over time. Here, we describe the design and baseline results of DEvELOP. We investigated the associations between core and suggestive DLB symptoms and different aspects of disease burden, i.e., instrumental activities of daily living (IADL) functioning, quality of life (QoL), and caregiver burden. We included 100 DLB patients (69?±?6?years, 10%F, MMSE 25?±?3) in the prospective DEvELOP cohort. Patients underwent extensive assessment including MRI, EEG/MEG, 123FP-CIT SPECT, and CSF and blood collection, with annual follow-up. Core (hallucinations, parkinsonism, fluctuations, RBD) and suggestive (autonomous dysfunction, neuropsychiatric symptoms) symptoms were assessed using standardized questionnaires. We used multivariate regression analyses, adjusted for age, sex, and MMSE, to evaluate how symptoms related to the Functional Activities Questionnaire, QoL-AD questionnaire, and Zarit Caregiver Burden Interview. In our cohort, RBD was the most frequently reported core feature (75%), while visual hallucinations were least frequently reported (39%) and caused minimal distress. Suggestive clinical features were commonly present, of which orthostatic hypotension was most frequently reported (64%). Ninety-five percent of patients showed EEG/MEG abnormalities, 88% of 123FP-CIT SPECT scans were abnormal, and 53% had a CSF Alzheimer’s disease profile. Presence of fluctuations, lower MMSE, parkinsonism, and apathy were associated with higher IADL dependency. Depression, constipation, and lower IADL were associated with lower QoL-AD. Apathy and higher IADL dependency predisposed for higher caregiver burden. Baseline data of our prospective DLB cohort show clinically relevant associations between symptomatology and disease burden. Cognitive and motor symptoms are related to IADL functioning, while negative neuropsychiatric symptoms and functional dependency are important determinants of QoL and caregiver burden. Follow-up is currently ongoing to address specific gaps in DLB research.
机译：具有Lewy Stogies项目（发展）的痴呆症旨在表型患有痴呆症的患者，具有Lewy体（DLB）并随着时间的推移研究症状和生物标志物。在这里，我们描述了发展的设计和基线结果。我们调查了核心和暗示DLB症状与疾病负担的不同方面的协会，即，日常生活（IADL）的工具活动，生活质量（QOL）和照顾者负担。我们包括100名DLB患者（69岁？±6？岁，预期发展队列中的10％F，MMSE 25？±3）。患者接受了广泛的评估，包括MRI，EEG / MEG，123FP-CIT SPECT和CSF和血液收集，随后进行了随访。使用标准化问卷评估核心（幻觉，帕金属，波动，RBD）和暗示（自主功能障碍，神经精神症状）症状。我们使用多元回归分析，调整为年龄，性别和MMSE，以评估与功能活动问卷，QOL广告问卷和Zarit Caregiver负担的症状的症状。在我们的队列中，RBD是最常见的核心特征（75％），而最少报告的视觉幻觉（39％）并导致最小的痛苦。暗示临床特征通常存在，其中最常报告过脱位的低血压（64％）。百分之九十五患者表现出EEG / MEG异常，占123FP-CIT SPECT扫描的88％异常，53％有CSF阿尔茨海默病的疾病概况。波动的存在，较低的MMSE，帕金森，和冷漠与较高的IADL依赖相关。抑郁症，便秘和较低的IADL与较低的QOL广告有关。冷漠和更高的IADL依赖性倾向于更高的护理人员负担。我们预期DLB队列的基线数据显示症状与疾病负担之间的临床相关联系。认知和电机症状与IADL功能有关，而阴性神经精神症状和功能依赖是QOL和护理人员负担的重要决定因素。随访目前正在进行解决DLB研究中的特定差距。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号