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首页> 外文期刊>Annals of Gastroenterological Surgery >Impact of postoperative complications after primary tumor resection on survival in patients with incurable stage IV colorectal cancer: A multicenter retrospective cohort study
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Impact of postoperative complications after primary tumor resection on survival in patients with incurable stage IV colorectal cancer: A multicenter retrospective cohort study

机译：原发性肿瘤切除后术后并发症对患者存活后的术后并发症的影响：多中心回顾队列队列研究

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Aims Primary tumor resection for patients with incurable stage IV colorectal cancer can prevent tumor-related complications but may cause postoperative complications. Postoperative complications delay the administration of chemotherapy and can lead to the spread of malignancy. However, the impact of postoperative complications after primary tumor resection on survival in patients with incurable stage IV colorectal cancer remains unclear. Therefore, this study aimed to investigate how postoperative complications after primary tumor resection affect survival in this patient group. Methods We reviewed data on 966 patients with stage IV colorectal cancer who underwent palliative primary tumor resection between January 2006 and December 2007. We examined the association between major complications (National Cancer Institute Common Terminology Criteria for Adverse Events v3.0 grade 3 or more) and overall survival using Cox proportional hazard model and explored risk factors associated with major complications using multivariable logistic regression analysis. Results Ninety-three patients (9.6%) had major complications. The 2-year overall survival rate was 32.7% in the group with major complications and 50.3% in the group with no major complications. Patients with major complications had a significantly poorer prognosis than those without major complications (hazard ratio: 1.62; 95% confidence interval: 1.21-2.18; P ?.01). Male, rectal tumor, and open surgery were identified to be risk factors for major complications. Conclusions Postoperative complications after primary tumor resection was associated with decreased long-term survival in patients with incurable stage IV colorectal cancer.
机译：针对阶段阶段阶段结直肠癌患者的原发性肿瘤切除可以预防肿瘤相关的并发症，但可能导致术后并发症。术后并发症延迟化疗施用，可以导致恶性肿瘤的传播。然而，术后并发症后术后并发症对患者存活后的术后并发症的影响尚不清楚。因此，本研究旨在调查原发性肿瘤切除后术后并发症如何影响该患者组的存活。方法介绍了2006年1月至2007年1月至12月在2007年1月至12月期间接受了姑息的原发性肿瘤切除术阶段IV型结直肠癌患者的数据。我们审查了主要并发症之间的关联（国家癌症学院的常见术语标准V3.0 3级或更多级）使用COX比例危害模型的整体存活和使用多变量逻辑回归分析的主要并发症相关的危险因素。结果九十三名患者（9.6％）具有重要的并发症。本集团的2年整体生存率为32.7％，具有重要并发症，50.3％，没有主要并发症。具有重要并发症的患者的预后显着较差，而不是没有主要并发症的那些（危险比：1.62; 95％置信区间：1.21-2.18; p <。01）。鉴定雄性，直肠肿瘤和开放手术是主要并发症的危险因素。结论原发性肿瘤切除后的术后并发症与可治区IV型结直肠癌患者的长期存活率下降有关。

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