...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >CD44-targeted pH-responsive micelles for enhanced cellular internalization and intracellular on-demand release of doxorubicin
【24h】

CD44-targeted pH-responsive micelles for enhanced cellular internalization and intracellular on-demand release of doxorubicin

机译：CD44靶向pH响应胶束，用于增强细胞内化和多柔比星的细胞内按需释放

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Poor cellular uptake and slow intracellular drug release remain the main barriers for the efficient application of micellar delivery system. Taking advantage of the overexpressed CD44 receptor and mild acidic microenvironment of tumour cells, CD44-targeted pH-responsive micelles based on the self-assembly of histidine–hyaluronic acid–dodecylamine (His–HA–DA) were prepared for the delivery of doxorubicin (DOX). These micelles exhibited pH-responsive behaviour with increased particle size, decreased encapsulation efficiency (EE%) of DOX and rapid release of DOX triggered by low pH. Compared with free DOX, DOX/HHD exhibited relatively high cellular uptake mainly via the CD44-mediated endocytosis. The on-demand intracellular release of DOX from DOX/HHD led to improved cytotoxicity. DOX/HHD also showed great penetration efficiency in 3D tumour spheres in?vitro . Moreover, these micelles with suitable particle size gained excellent tumour-targeting effects, as well as improved anti-tumour effects and reduced side effects in?vivo . In conclusion, these micelles with CD44 targeted and pH-responsive behaviours provide a promising strategy for the efficient delivery of anti-tumour drugs in?vivo .
机译：可怜的细胞摄取和细胞内缓慢释放药物仍然是胶束输送系统的有效应用的主要障碍。以过表达的CD44受体和肿瘤细胞的温和的酸性微环境的优点，CD44靶向基于所述自组装的组氨酸 - 透明质酸的酸十二烷基胺（HIS-HA-DA）pH响应胶束为多柔比星的递送（制备dox）。这些表现出pH响应行为具有增加的粒径胶束，降低DOX和DOX的快速释放的封装效率（EE％）由低pH引起的。与游离DOX相比，DOX / HHD表现出相对高的细胞摄取主要经由CD44介导的内吞作用。从DOX / HHD DOX的点播细胞内释放导致改善细胞毒性。 Dox / HHD在体外3D肿瘤球体中还显示出良好的渗透效率。此外，这些微胶粒具有合适的粒径获得优异的肿瘤靶向效果，以及改善的抗肿瘤效果和降低的副作用在？体内。总之，这些胶束CD44针对性和pH响应行为提供了吗？体内有效传递的抗肿瘤药物有前途的战略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号