...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >A polymer–lipid membrane artificial cell nanocarrier containing enzyme–oxygen biotherapeutic inhibits the growth of B16F10 melanoma in 3D culture and in a mouse model
【24h】

A polymer–lipid membrane artificial cell nanocarrier containing enzyme–oxygen biotherapeutic inhibits the growth of B16F10 melanoma in 3D culture and in a mouse model

机译：含有酶 - 氧生物治疗性的聚合物 - 脂膜人造细胞纳米载体抑制了3D培养和小鼠模型中B16F10黑素瘤的生长

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Melanoma is a deadly skin cancer. Surgery is effective for early stages but there may be remnant cells. Treatments of later stages are associated with severe side effects. Moreover, a dangerous type of melanoma cannot be detected early enough for surgery. There is an urgent need for treatment with less severe side effects. We use a novel system of artificial cell polymer–lipid membrane nanocarrier containing a biomolecular nano-system of enzyme–oxygen biotherapeutic. In this report we show (1) its effectiveness and mechanisms in inhibiting the growth of melanoma in a 3D culture collagen medium that is more similar to that in the animal. (2) This allows us to design and carry out animal studies to successfully show that this can inhibit the growth of melanoma in an animal model. This includes following the tumour sizes and body weights every 2?days for 30?days followed by histology of the sites of injection and vital organs. We also analyze the action of the different components of the nanocarrier–nano-biotherapeutic complex. In conclusion, the results show the safety and clinical feasibility of this approach in the animal model and encourages further study towards clinical use.
机译：黑色素瘤是一种致命的皮肤癌。手术对早期阶段有效，但可能有残留细胞。后期阶段的治疗与严重的副作用有关。此外，对于手术，不能检测到危险类型的黑素瘤。迫切需要治疗较严重的副作用。我们使用含有酶 - 氧生物治疗生物分子纳米系统的人造细胞聚合物 - 脂质膜纳米载体的新型系统。在本报告中，我们展示（1）其有效性和机制，抑制3D培养胶原介质中黑色素瘤的生长，其与动物更类似于该培养基。 （2）这使我们能够设计和开展动物研究以成功地表明这可以抑制动物模型中黑素瘤的生长。这包括在肿瘤尺寸和体重每2次肿瘤尺寸和体重30？天，然后是注射和重要器官的部位的组织学。我们还分析了纳米载体 - 纳米 - 生物治疗复合物的不同组分的作用。总之，结果表明这种方法在动物模型中的安全性和临床可行性，并鼓励进一步研究临床使用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号