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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Anti-microbial and anti-cancer activities of Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 ?(x ≤ 0.1) nanoparticles
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Anti-microbial and anti-cancer activities of Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 ?(x ≤ 0.1) nanoparticles

机译：抗微生物和抗癌活性Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4？（x≤0.1）纳米颗粒

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Combining two or more nanoparticles is a promising approach. Previously we have reported synthesis of nanoparticles Dysprosium (Dy) substituted with manganese (Mn) zinc (Zn) by using ultrasonication method. The five different nanoparticles (NPs) Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 ( x ≤?0.1) have been structurally and morphologically characterized but there is no report on the biological application of these NPs. In the present study, we have examined the anti-cancer, anti-bacterial, and anti-fungal activities of Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 ( x ≤?0.1) NPs. Human colorectal carcinoma cells (HCT-116) were tested with different concentrations of NPs by using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. In addition, the impact of NPs was also examined on normal cells such as human embryonic kidney cells, HEK-293. After 48?h of treatment, Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 NPs ( x =?0.02, 0.04 and 0.06) showed no inhibitory action on cancer cell’s growth and proliferation, whereas Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 NPs ( x =?0.08 and 0.1) showed profound inhibitory action on cancer cell’s growth and proliferation. However, the treatment of Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 NPs on the normal cells (HEK-293) did not show cytotoxic or inhibitory action on HEK-293 cells. The treatment of Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 NPs ( x ≤?0.1) also inhibited both the bacteria ( Escherichia coli ATCC35218 and Staphylococcus aureus ) with lowest MIC and MBC values of 4 and 8?mg/mL and fungus ( Candida albicans ) with MIC and MFC values of 4 and 8?mg/mL on treatment with x =?0.08 and 0. 1.
机译：组合两种或更多种纳米颗粒是一种有希望的方法。以前我们通过使用超声方法报道了用锰（Mn）锌（Zn）取代的纳米颗粒镝（Dy）的合成。五种不同的纳米颗粒（NPS）Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4（x≤≤0.1）在结构上和形态学表现，但没有关于这些NP的生物学应用的报告。在本研究中，我们研究了Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4（x≤≤0.1）nps的抗癌，抗菌和抗真菌活性。通过使用MTT [3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴]测定，用不同浓度的NPS测试人结肠直肠癌细胞（HCT-116）。此外，还在对人胚胎肾细胞如人胚胎肾细胞，HEK-293等正常细胞上检查NPS的影响。在48℃的处理后，Mn 0.5 Zn 0.5 Dy X Fe 2-X O 4 NPS（x = 0.02,0.04和0.06）显示出对癌细胞的生长和增殖的抑制作用，而Mn 0.5 Zn 0.5 dy x Fe 2 -X o 4 nps（x = 0.08和0.1）显示出对癌细胞的生长和增殖的深远抑制作用。然而，在正常细胞（HEK-293）上的Mn 0.5 Zn 0.5 Dy X Fe 2-X O 4 NP的处理未显示在HEK-293细胞上的细胞毒性或抑制作用。 Mn 0.5 Zn 0.5 Dy x Fe 2-x O 4 nps（x≤≤0.1）的处理也抑制了具有最低MIC和4和8？mg / ml的细菌（大肠杆菌ATCC35218和金黄色葡萄球菌）和MBC值真菌（Candida albicans）用麦克风和MFC值为4和8？mg / ml，用x = 0.08和0.1。

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