• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Influenza and other respiratory viruses. >Assessment of the benefits of seasonal influenza vaccination: Elements of a framework to interpret estimates of vaccine effectiveness and support robust decision‐making and communication
【24h】

Assessment of the benefits of seasonal influenza vaccination: Elements of a framework to interpret estimates of vaccine effectiveness and support robust decision‐making and communication

机译：评估季节性流感疫苗接种的益处：框架的要素，以解释疫苗效力估计和支持强大的决策和沟通

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Systematic reviews and meta-analyses confirm that influenza vaccination reduces the risk of influenza illness by between about 40% and 60% in seasons when circulating influenza stains are well matched to vaccine strains. Influenza vaccine effectiveness (IVE) estimates, however, are often discordant and a source of confusion for decision makers. IVE assessments are increasingly publicized and are often used by policy makers to make decisions about the value of seasonal influenza vaccination. But there is limited guidance on how IVE should be interpreted or used to inform policy. There are several limitations to the use of IVE for decision-making: (a) IVE studies have methodological issues that often complicate the interpretation of their value; and (b) the full impact of vaccination will almost always be greater than the impact assessed by a point estimate of IVE in specific populations or settings. Understanding the strengths and weaknesses of study methodologies and the fundamental limitations of IVE estimates is important for the accuracy of interpretations and support of policy makers' decisions. Here, we review a comprehensive set of issues that need to be considered when interpreting IVE and determining the full benefits of influenza vaccination. We propose that published IVE values should be assessed using an evaluative framework that includes influenza-specific outcomes, types of VE study design, and confounders, among other factors. Better interpretation of IVE will improve the broader assessment of the value of influenza vaccination and ultimately optimize the public health benefits in seasonal influenza vaccination.? 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
机译：系统评价和荟萃分析证实，当循环流感污渍与疫苗菌株相匹配时，流感疫苗接种疫苗会使流感疾病的风险降低约40％和60％。然而，流感疫苗有效性（IVE）估计通常不和谐，决策者的混乱来源往往不和谐。 IVE评估越来越受到宣传，并经常被决策者使用，以决定季节性流感疫苗接种的价值。但有限的指导意见应如何解释或用于通知政策。使用IVE进行决策有几个局限性：（a）我的研究具有往往使他们的价值的解释复杂化的方法问题; （b）疫苗接种的全部影响几乎总是大于在特定群体或环境中对IVE的点估计评估的影响。了解研究方法的优势和弱点以及IVE估计的基本局限性对于政策制定者决定的解释和支持的准确性非常重要。在这里，我们审查了一系列全面的问题，需要在解释我和确定流感疫苗接种的全部益处时需要考虑。我们建议使用具有型自然的结果，VE研究设计和混淆的评价框架来评估公布的IVE值，以及其他因素。更好地解释IVE将改善流感疫苗接种价值的更广泛评估，并最终优化季节性流感疫苗接种的公共卫生益处。 2020作者。 John Wiley＆Sons Ltd.出版的流感和其他呼吸病毒

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号