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首页> 外文期刊>Influenza and other respiratory viruses. >Incidence of influenza virus infections confirmed by serology in children and adult in a suburb community, northern China, 2018‐2019 influenza season
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Incidence of influenza virus infections confirmed by serology in children and adult in a suburb community, northern China, 2018‐2019 influenza season

机译：流感病毒感染的发病率在郊区社区中的儿童和成人血清学证实，中国北部，2018-2019流感季节

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BACKGROUND:In mainland China, seasonal influenza disease burden at community level is unknown. The incidence rate of influenza virus infections in the community is difficult to determine due to the lack of well-defined catchment populations of influenza-like illness surveillance sentinel hospitals.OBJECTIVES:We established a community-based cohort to estimate incidence of seasonal influenza infections indicated by serology and protection conferred by antibody titers against influenza infections during 2018-2019 influenza season in northern China.METHODS:We recruited participants in November 2018 and conducted follow-up in May 2019 with collection of sera every survey. Seasonal influenza infections were indicated by a 4-fold or greater increase of hemagglutination inhibition (HI) antibody between paired sera.RESULTS:Two hundred and three children 5-17?years of age and 413 adults 18-59?years of age were followed up and provided paired sera. The overall incidence of seasonal influenza infection and incidence of A(H3N2) infection in children (31% and 17%, respectively) were significantly higher than those in adults (21% and 10%, respectively). The incidences of A(H1N1)pdm09 infection in children and adults were both about 10%, while the incidences of B/Victoria and/Yamagata infection in children and adults were from 2% to 4%. HI titers of 1:40 against A(H1N1)pdm09 and A(H3N2) viruses were associated with 63% and 75% protection against infections with the two subtypes, respectively.CONCLUSIONS:In the community, we identified considerable incidence of seasonal influenza infections. A HI titer of 1:40 could be sufficient to provide 50% protection against influenza A virus infections indicated by serology.? 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
机译：背景：在中国大陆，社区一级的季节性流感病重是未知的。由于缺乏缺乏血型疾病疾病监督哨所医院的缺乏明确的流域种群，难以确定的流感病毒感染的发病率。目的：我们建立了一个社区的群组，以估算季节性流感感染的发病率通过血清学和保护赋予北部2018 - 2019年流感季节的抗体滴度。方法：我们在2018年11月招募了参与者，并于2019年5月进行了随访，每次调查都有塞马。季节性流感感染是指配合血清之间的4倍或更大的血凝抑制（HI）抗体增加或更大的增加：一百年和三十岁儿童5-17岁及413岁，18-59岁？岁月向上和提供配对的血清。儿童季节性流感感染和发病率（分别为31％和17％）的整体发病率（分别为31％和17％）显着高于成人（分别为21％和10％）。儿童和成年人的（H1N1）PDM09感染的发病率均约为10％，而B / Victoria和/ Yamagata感染的发病率为儿童和成年人的发病率均值为2％至4％。 1:40的HI滴度对（H1N1）PDM09和（H3N2）病毒分别与两种亚型的63％和75％的保护相关。结论：在社区中，我们确定了季节性流感感染的相当大的发病率。 1:40的Hi Titer可以足以提供50％的免受血清学病毒感染的50％的保护。 2020作者。 John Wiley＆Sons Ltd.出版的流感和其他呼吸病毒

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