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首页> 外文期刊>International Journal of Electrochemical Science >Au-Ag nanoparticles-graphene quantum dots as sensor for highly sensitive electrochemical determination of insulin level in pharmaceutical samples
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Au-Ag nanoparticles-graphene quantum dots as sensor for highly sensitive electrochemical determination of insulin level in pharmaceutical samples

机译：Au-Ag纳米颗粒 - 石墨烯量子点作为用于高敏感的电化学测定药物样品中胰岛素水平的传感器

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This study was performed on the synthesis of Au-Ag nanoparticles-graphene quantum dots (Au-Ag NPs/GQDs) as a highly sensitive electrochemical sensor of insulin levels in prescription drugs for type 2 diabetic patients. To fabricate the Au-Ag NPs/GQDs modified GCE electrode (Au-Ag NPs/GQDs/GCE), GQDs were synthesized using the hydrothermal method on GCE, and then AuAgNPs were electrodeposited on GQDs/GCE. The structural analyses of Au-Ag NPs/GQDs/GCE using SEM and XRD showed uniform coverage of the bimetallic nanoparticles in fcc crystal structure on the GQDs. The electrochemical studies for determination of insulin using CV and DPV showed that the linear range, limit of detection and sensitivity were obtained 10 to 120 μM, 1.1 nM and 0.24184μA/μM, respectively which were comparable or better than sensing results of other reported insulin sensors in literature. The selectivity of proposed insulin sensor was investigated in presence of biological species human serum sample such as thiourea, glucose, methionine, cysteine, ascorbic acid, uric acid and glutathione and results indicated the interference biological species did not show any interference effect on insulin determination. The applicability of sensor was studied for the determination of insulin in insulin glargine injection sample and results exhibited to the acceptable values for recovery and RSD, demonstrating the proposed sensor can be used as reliable and precise sensor to determine insulin in biological and clinical samples.
机译：该研究是对Au-Ag纳米颗粒 - 石墨烯量子点（Au-Ag NPS / GQD）的合成作为2型糖尿病患者的处方药中胰岛素水平的高敏感电化学传感器进行。为了制造Au-Ag NPS / GQDS改性的GCE电极（AU-AG NPS / GQDS / GCE），使用GCE上的水热法合成GQD，然后在GQD / GCE上电沉积AuAgnps。使用SEM和XRD的AU-AG NPS / GQDS / GCE的结构分析显示了GQDS上FCC晶体结构中的双金属纳米颗粒的均匀覆盖。使用CV和DPV测定胰岛素的电化学研究表明，分别获得10至120μm，1.1nm和0.24184μA/μm的线性范围，检测极限，1.1nm和0.24184μA/μm。比其他报告的胰岛素的感测结果相当或更好文学中的传感器。在生物物种人血清样品如硫脲，葡萄糖，甲硫氨酸，半胱氨酸，抗坏血酸，尿酸和谷胱甘肽的存在下，研究了所提出的胰岛素传感器的选择性，并表明干扰生物物种没有对胰岛素测定的任何干扰作用。研究了传感器的适用性，用于测定胰岛素中的胰岛素注射样品中的胰岛素，并表现出恢复和RSD的可接受值的结果，证明所提出的传感器可用作可靠和精确的传感器，以确定生物和临床样品中的胰岛素。

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