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首页> 外文期刊>International Journal of Electrochemical Science >Electrochemical Biosensor for the Determination of Sufentanil in Human Plasma and Urine based on TiO2?-Graphene Composite modified carbon paste electrode
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Electrochemical Biosensor for the Determination of Sufentanil in Human Plasma and Urine based on TiO2?-Graphene Composite modified carbon paste electrode

机译：基于TiO2β型复合材料改性碳浆电极的人血浆和尿液中苏芬太尼测定的电化学生物传感器

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摘要

In this work, the synthesis of TiO2 and graphene nanocomposite modified carbon paste electrode (TiO2-GO/CPE) as an electrochemical biosensor for the detection of sufentanil in human plasma and urine was investigated. The modified Hummers approach was used to synthesize GO nanosheets, and the hydrothermal approach was used to produce TiO2-GO nanocomposite. Due to the interaction of TiO2 nanoparticles with GO, structural studies of the produced nanocomposite using SEM and XRD revealed that TiO2 nanoparticles in anatase structure had been anchored to GO's nanosheets surface. Electrochemical studies using CV revealed that TiO2-GO/CPE had higher electrocatalytic current and lower potential than GO/CPE and CPE for determination of sufentanil due to the synergetic effect of high electrical conductivity of GO nanosheets and intercalation of TiO2 nanoparticles on nanocomposites. The sensitive, stable, and rapid response of TiO2-GO/CPE was demonstrated in amperometric tests for the detection of sufentanil. The limit of detection, sensitivity and linear range for the determination of sufentanil was obtained at 0.07nM, 4.1070μA/μM, and 1 to 10 μM, respectively. The ability of TiO2-GO/CPE as a sufentanil sensor in prepared real samples of urine and human plasma showed that the performance of TiO2-GO/CPE to determine sufentanil in real samples was adequate and acceptable.
机译：在这项工作中，研究了TiO 2和石墨烯纳米复合材料改性碳浆料（TiO2-GO / CPE）作为用于检测人血浆和尿液中的苏芬太尼的电化学生物传感器的合成。修饰的悍马方法用于合成GO纳米片，水热方法用于产生TiO2-Go纳米复合材料。由于TiO2纳米颗粒与GO的相互作用，使用SEM和XRD的产生的纳米复合材料的结构研究表明，锐钛矿结构中的TiO2纳米颗粒已被锚固到纳米片表面。使用CV的电化学研究显示，由于GO纳米片的高导电性和TiO2纳米颗粒的嵌入在纳米复合材料上的纳米粒子的嵌入，TiO2-Go / CPE具有更高的电催化电流和低潜力。在Amfenticanil检测的安培测定试验中证明了TiO2-Go / CPE的敏感，稳定和快速响应。测定苏芬太尼的检测极限，敏感性和线性范围分别以0.07Nm，4.1070μA/μm和1至10μm获得。 TiO2-Go / CPE作为尿液和人血浆制备的真正样品中的素丹尼尔传感器的能力表明，TiO2-Go / CPE在真实样品中测定Sufentanil的性能是足够的并且可以接受。

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