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首页> 外文期刊>Eastern Journal of Medicine >Diagnostic value of neutrophil to lymphocyte ratio for assessing the disease severity in covid-19 patients
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Diagnostic value of neutrophil to lymphocyte ratio for assessing the disease severity in covid-19 patients

机译：中性粒细胞对淋巴细胞比率评估Covid-19患者疾病严重程度的诊断价值

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Diagnostic value of neutrophil to lymphocyte ratio for assessing the disease severity in covid-19 patients Ngakan Ketut Wira Suastika 1 , Ketut Suega 2 1 Division Of Hematology And Medical Oncology, Department Of Internal Medicine, Faculty Of Medicine, Udayana University; Udayana University Hospital, Bali, Indonesia 2 Division Of Hematology And Medical Oncology, Department Of Internal Medicine, Faculty Of Medicine, Udayana University; Sanglah General Hospital, Bali Indonesia INTRODUCTION: Deterioration of the clinical condition in corona virus disease 2019 (Covid-19) patients can be rapid and unpredictable. A sensitive biomarker is required to assess the disease severity to anticipate these condition. Neutrophil to lymphocyte ratio (NLR) is easily calculated from a complete blood count parameters, so it can be used as a biomarker to assess disease severity in Covid-19 patients. METHODS: Patients characteristic and NLR were obtained from patients confirmed by Covid-19 at Udayana University Hospital, Bali, Indonesia from April to September 2020. The Mann Whitney U test is used to determine the difference of NLR in severe and non-severe cases of Covid-19. The receiver operating characteristic curve (ROC) is used to determine the optimal cut-off value, sensitivity, specificity, and area under curve (AUC) of the NLR in assessing disease severity in Covid-19 patients. Binary logistic regression analysis was performed to determine the effect of age, comorbidities and other significant variables that have a significant effect on disease severity. RESULTS: A total of 411 patients were included in this study. We found a significant difference of NLR between severe and non-severe cases of Covid-19 (p 0.001). We found an optimal NLR cut-off value of 3.0, with 81.4% sensitivity, 81.2% specificity, and area under curve of 0.886 (95% confidence interval (CI) 0.848 ? 0.923; p 0.001). DISCUSSION AND CONCLUSION: Neutrophil to lymphocyte ratio is a biomarker that has a high diagnostic value for assessing the disease severity in Covid-19 patients.
机译：中性粒细胞对淋巴细胞比率评估疾病严重程度的诊断价值，用于评估Covid-19患者Ngakan ketut Wira Sustika 1，Ketut Suega 2 1血液学和医学肿瘤科，医学系，医学院，Udayana大学医学院; Udayana大学医院，巴厘岛，印度尼西亚2号血液学和医学肿瘤科，内科，医学院，Udayana University;巴厘岛印度尼西亚桑拉海综合医院介绍：2019（Covid-19）患者的临床状况恶化（Covid-19）患者可以快速和不可预测。需要一种敏感的生物标志物来评估疾病严重程度以预期这些病症。从完整的血液计数参数容易地计算淋巴细胞比（NLR）的中性粒细胞，因此它可以用作生物标志物，以评估Covid-19患者的疾病严重程度。方法：患者特征和NLR是由Covid-19在Upony Aconia的4月20日至9月到9月的Covid-19证实的患者获得的。Mann Whitney U测试用于确定NLR在严重和非严重情况下的NLR差异2019冠状病毒病。接收器操作特征曲线（ROC）用于确定NLR的曲线（AUC）下的最佳截止值，敏感性，特异性和区域，用于评估Covid-19患者的疾病严重程度。进行二元逻辑回归分析以确定年龄，合并症和其他显着变量对疾病严重程度有显着影响的影响。结果：本研究共纳入411名患者。我们发现在Covid-19的严重和非严重案例之间的NLR差异有显着差异（P <0.001）。我们发现最佳NLR截止值为3.0，灵敏度为81.4％，特异性81.2％，曲线下面积为0.886（95％置信区间（CI）0.848; 0.923; 0.923）。讨论和结论：淋巴细胞比的中性粒细胞是一种生物标志物，其具有高诊断价值，用于评估Covid-19患者的疾病严重程度。

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