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首页> 外文期刊>Eastern Journal of Medicine >Phenotypic and Genotypic Analysis of the Antibiotic Resistance Profiles of Gram Negative Bacteria Isolated from the Blood Culture Samples
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Phenotypic and Genotypic Analysis of the Antibiotic Resistance Profiles of Gram Negative Bacteria Isolated from the Blood Culture Samples

机译：从血液培养样品中分离的革兰阴性细菌的抗生素抗性谱的表型和基因型分析

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Phenotypic and Genotypic Analysis of the Antibiotic Resistance Profiles of Gram Negative Bacteria Isolated from the Blood Culture Samples ?mer Akgül 1 , Gülhan ARVAS 1 , AL? KU?TAN 2 1 Department Of Pharmaceutical Microbiology, Faculty Of Pharmacy, Van Yüzüncü Y?l University, Van, Turkey 2 Department Of Pharmaceutical Microbiology, Instituted Of Health Sciences, Van Yüzüncü Y?l University,van, Turkey INTRODUCTION: Sepsis, which is common and often lethal, is a serious public health problem. There is consensus that the incidence is increased in patients with sepsis due to an aging population, increased use of immunosuppressive therapy, and high-risk interventions. METHODS: Seven hundred fifty patients with suspected sepsis hospitalized in intensive care units in the Health Education University Van Training and Research Hospital were evaluated. 750 patients were classified according to their age and sex. Bacteria were isolated from their blood cultures. Biochemical tests such as catalase test, oxidase test and Gram staining were performed. Vitek 2 Compact (Biomerieux, USA) device was used for identification of bacteria and evaluation of the antibiogram test. The blaOXA-48 and blaIMP genes were analyzed by polymerase chain reaction (PCR). RESULTS: Ten multidrug-resistant bacteria were isolated and identified from patients with sepsis. Of our gram negative bacteria, only 2 K. pneumoniae isolates were found to be blaOXA-48 carriers. No blaIMP gene was found in any of our gram negative bacteria causing sepsis. DISCUSSION AND CONCLUSION: ?dentification of the bacteria causing sepsis in our hospital and determining the antibiotic resistance rates were found quite important. Among the causative agents of bloodstream enfections, effect of the presence of carbapenem, enlarged β-lactamase and multidrug resistance bacteria on human health were found to be very important.
机译：从血液培养样品中分离的革兰阴性细菌的抗生素抗性曲线的表型和基因型分析？MERAKGÜL1，GülhanArvas1，Al？ ku？谭21药房医学系，vanYüzüncüy？Lyüzüncüy？Luisty，Purkey 2药物微生物学系，vanYüzüncüy制作医药微生物学，VanYüzüncüy？L University，Van，土耳其介绍：Sepsis，哪种是常见的，通常是致命的，是一个严重的公共卫生问题。由于人口老龄化，脓毒症患者，脓毒症患者的发病率增加了共识，增加了免疫抑制治疗和高风险干预措施。方法：评估七百五十名患有脓毒症的疑似脓毒症患者，在健康教育大学范培范培训和研究医院住院。 750名患者根据年龄和性别进行分类。从血液培养物中分离细菌。进行生化试验，如过氧化氢酶试验，氧化酶试验和革克染色。 Vitek 2 Compact（Biomerieux，USA）装置用于鉴定细菌和抗诊断测试的评估。通过聚合酶链式反应（PCR）分析Blaoxa-48和Blaimp基因。结果：分离10个多药抗性细菌，并从败血症患者中鉴定。我们的革兰氏阴性细菌，发现肺炎群岛分离物仅被发现是Blaoxa-48载体。在我们的任何革兰氏阴性细菌中发现了Blaimp基因，导致败血症。讨论和结论：抑制我们院中脓毒症的细菌的牙科并确定抗生素抗性率非常重要。在血流enfection的致病药中，发现鲤鱼蛋白，扩大β-内酰胺酶和多药耐药细菌对人体健康的影响非常重要。

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