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Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

机译：更新了血清尿酸水平和牛皮癣升高之间的关联的证据

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Background: Our earlier meta-analysis showed that the correlation between psoriasis and hyperuricemia might be region-dependent and that hyperuricemia was more common in patients with psoriasis in Western Europe. However, no further analysis could be conducted owing to the scarcity of data. Objective: Our study aimed to further explore the association between psoriasis and hyperuricemia. Methods: Six databases (PubMed, Embase, the Cochrane Central Register of Controlled Trials, the China National Knowledge Infrastructure database, the Chinese Scientific Journals Full Text Database, and the Wanfang Data Knowledge Service Platform) were searched for studies published between January 1980 and February 2021. Results: The search strategy yielded 291 relevant studies, of which 27 observational studies were included in this analysis. Serum uric acid (SUA) levels (mean difference [MD] 0.99, 95% confidence interval [CI] 0.48–1.49, P = 0.0001) and hyperuricemia frequency (odds ratio [OR] 5.39, 95% CI 1.88–15.40, P = 0.002) were higher in the psoriasis group than in the control group, and the subgroup differences were significant. In addition, SUA levels were significantly higher in patients with moderate to severe psoriasis from European and American countries (MD 0.89, 95% CI 0.18–1.60, P = 0.01) and Southeast Asia (MD 1.79, 95% CI 0.55–3.02, P = 0.004), while no significant differences were found between the Middle East subgroup (MD 0.63, 95% CI ?0.33 to 1.59, P = 0.20). Similar results were obtained from the meta-analysis of SUA levels in patients with metabolic syndrome, obesity, or a special type of psoriasis (such as arthritic or erythrodermic psoriasis). Conclusions: Our meta-analysis study provides extended data regarding the correlation between psoriasis and hyperuricemia and the differences in SUA levels between psoriasis patients and controls in Southeast Asia, the Middle East, and European and American countries. Patients with moderate to severe psoriasis in European and American countries and Southeast Asia or those with metabolic syndrome and obesity were more likely to have higher uric acid levels. Systematic Review Registration: PROSPERO, identifier: CRD42014015091.
机译：背景：我们之前的荟萃分析表明，牛皮癣和高尿酸血症之间的相关性可能是区域依赖性的，并且在西欧的牛皮癣患者中，高尿酸血症更常见。但是，由于数据的稀缺，无法进一步分析。目的：我们的研究旨在进一步探索牛皮癣和高尿酸血症之间的关联。方法：六个数据库（PubMed，Embase，受控试验的Cochrane Central Ressions寄存器，中国国家知识基础设施数据库，中国科学期刊全文数据库以及WANFANG数据知识服务平台）于1980年1月和2月发布的研究结果：结果：搜查策略产生了291项相关研究，其中包括27个观察性研究。血清尿酸（SUA）水平（平均差异[MD] 0.99,95％置信区间[CI] 0.48-1.49，p = 0.0001）和高尿酸血症频率（差距[或] 5.39,95％CI 1.88-15.40，P =在牛皮癣组中比对照组在牛皮癣组中较高，亚组差异显着。此外，来自欧洲和美国国家中度至严重牛皮癣的患者的SUA水平显着高（MD 0.89,95％CI 0.18-1.60，P = 0.01）和东南亚（MD 1.79,95％CI 0.55-3.02，P = 0.004），而中东亚组（MD 0.63,95％CIα0.33至1.59，P = 0.20）没有发现显着差异。从代谢综合征，肥胖症或特殊类型的牛皮癣（如关节炎或红斑狼疮）的患者的SUA水平的META分析中获得了类似的结果。结论：我们的META分析研究提供了关于牛皮癣和高尿酸血症之间的相关性的扩展数据，以及东南亚，中东和欧洲国家的牛皮癣患者和控制之间的SUA水平的差异。欧洲和美国国家和东南亚的严重牛皮癣或代谢综合征和肥胖的患者更有可能具有更高的尿酸水平。系统审查登记：Prospero，标识符：CRD42014015091。

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