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首页> 外文期刊>Frontiers in Medicine >Non-ionizing 405 nm Light as a Potential Bactericidal Technology for Platelet Safety: Evaluation of in vitro Bacterial Inactivation and in vivo Platelet Recovery in Severe Combined Immunodeficient Mice
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Non-ionizing 405 nm Light as a Potential Bactericidal Technology for Platelet Safety: Evaluation of in vitro Bacterial Inactivation and in vivo Platelet Recovery in Severe Combined Immunodeficient Mice

机译：非电离405nm光作为血小板安全性的潜在杀菌技术：对体外细菌灭活和体内血小板恢复的评估严重组合免疫缺陷小鼠

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摘要

Bacterial contamination of ex vivo stored platelets is a cause of transfusion-transmitted infection. Violet-blue 405 nm light has recently demonstrated efficacy in reducing the bacterial burden in blood plasma, and its operational benefits such as non-ionizing nature, penetrability, and non-requirement for photosensitizing agents, provide a unique opportunity to develop this treatment for in situ treatment of ex vivo stored platelets as a tool for bacterial reduction. Sealed bags of platelet concentrates, seeded with low-level Staphylococcus aureus contamination, were 405 nm light-treated (3–10 mWcm ?2 ) up to 8 h. Antimicrobial efficacy and dose efficiency was evaluated by quantification of the post-treatment surviving bacterial contamination levels. Platelets treated with 10 mWcm ?2 for 8 h were further evaluated for survival and recovery in severe combined immunodeficient (SCID) mice. Significant inactivation of bacteria in platelet concentrates was achieved using all irradiance levels, with 99.6–100% inactivation achieved by 8 h ( P 0.05). This report paves the way for further comprehensive studies to test 405 nm light treatment as a bactericidal technology for stored platelets.
机译：离体储存血小板的细菌污染是输血传播感染的原因。紫蓝色405 nm光最近证明了降低血浆中细菌负担的功效，其运行益处，如非电离性质，渗透性和对光敏剂的不要求，提供了开发这种治疗的独特机会原位处理离体储存的血小板作为细菌还原的工具。用低水平的葡萄球菌污染接种的血小板浓缩物的密封袋，可染色405nm，高达8小时。通过定量治疗后存活的细菌污染水平评价抗微生物功效和剂量效率。用10mMCMβ2治疗的血小板2小时，以进一步评估严重组合免疫缺陷（SCID）小鼠的存活和恢复。使用所有辐照水平达到血小板浓缩物中细菌的显着灭活，通过8小时实现了99.6-100％的灭活（P 0.05）。本报告铺平了进一步全面研究的方式，以测试405 nm轻的处理作为储存血小板的杀菌技术。

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