...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Medicine >Interplay Between Microbiota, Toll-Like Receptors and Cytokines for the Maintenance of Epithelial Barrier Integrity
【24h】

Interplay Between Microbiota, Toll-Like Receptors and Cytokines for the Maintenance of Epithelial Barrier Integrity

机译：Interplay的 菌群 ， Toll样受体 与细胞因子 对 上皮屏障 完整性 的 维护

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The intestinal tract is densely populated by microbiota consisting of various commensal microorganisms that are instrumental for the healthy state of the living organism. Such commensals generate various molecules that can be recognized by the Toll-like receptors of the immune system leading to the inflammation marked by strong upregulation of various proinflammatory cytokines, such as TNF, IL-6, and IL-1β. To prevent excessive inflammation, a single layer of constantly renewing, highly proliferating epithelial cells (IEC) provides proper segregation of such microorganisms from the body cavities. There are various triggers which facilitate the disturbance of the epithelial barrier which often leads to inflammation. However, the nature and duration of the stress may determine the state of the epithelial cells and their responses to cytokines. Here we discuss the role of the microbiota-TLR-cytokine axis in the maintenance of the epithelial tissue integrity. In particular, we highlight discrepancies in the function of TLR and cytokines in IEC barrier during acute or chronic inflammation and we suggest that intervention strategies should be applied based on the type of inflammation.
机译：肠道被微生物菌浓密地填充，Microbiota由各种非聚合物微生物组成，这些微生物是用于生物体健康状态的乐器。这种共同产生各种分子，其可以通过免疫系统的可达浊的受体识别，导致通过各种促炎细胞因子的强大上调的炎症，例如TNF，IL-6和IL-1β。为了防止过量炎症，单层不断更新，高增殖的上皮细胞（IEC）提供了从体腔中的这种微生物的适当偏析。存在各种触发器，其促进了上皮屏障的干扰，这通常导致炎症。然而，应力的性质和持续时间可以确定上皮细胞的状态及其对细胞因子的反应。在这里，我们讨论了微生物群-TLR-Cytokine轴在上皮组织完整性中的作用。特别是，在急性或慢性炎症期间，我们突出了IEC屏障中TLR和细胞因子的功能的差异，并建议应根据炎症的类型施加干预策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号