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首页> 外文期刊>Reproductive Biology and Endocrinology >No significant long-term complications from inadvertent exposure to gonadotropin-releasing hormone agonist during early pregnancy in mothers and offspring: a retrospective analysis
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No significant long-term complications from inadvertent exposure to gonadotropin-releasing hormone agonist during early pregnancy in mothers and offspring: a retrospective analysis

机译：在母亲和后代早期怀孕期间无意中暴露于促性腺激素释放激素激动剂的无意中并发症：回顾性分析

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Administration of gonadotropin-releasing hormone agonist (GnRH-a) in the luteal phase is commonly used for pituitary suppression during in vitro fertilisation (IVF). There is an ineluctable risk of inadvertent exposure of spontaneous pregnancy to GnRH-a. However, little is known about the pregnancy complications and repregnancy outcomes of the affected women and the neurodevelopmental outcomes of the GnRH-a-exposed children. Retrospective analysis was used to determine obstetric and repregnancy outcomes after natural conception in 114 women who naturally conceived while receiving GnRH-a during their early pregnancy over the past 17?years. The GnRH-a-exposed children were evaluated to determine their neonatal characteristics and long-term neurodevelopmental outcomes. The outcomes were compared to those of relevant age-matched control groups. Sixty-five women had 66 live births. The neonatal health outcomes and the incidence of maternal complications were similar in the GnRH-a-exposed and control groups. Thirty-one GnRH-a-exposed children, aged 2–8?years, were available for investigation of neurodevelopment. Except for one case of autism spectrum disorder, the full-scale intelligence quotient score was within the normal range and similar to that of the control group. Most mothers with successful pregnancies and about one-third of the women who had spontaneous abortions were subsequently able to conceive naturally again. IVF is recommended for repregnancy in women who have experienced ectopic pregnancies. Accidental exposure to GnRH-a in early pregnancy might be safe. Reproductive treatment suggestions for repregnancy should be made with consideration of the outcomes of the previously GnRH-a-exposed spontaneous pregnancy.
机译：在体外施肥期间，肝脏释放激素激动激素激动剂（GnRH-A）常用于垂体抑制（IVF）。无可置动的风险无意中暴露于天然妊娠对GNRH-A。然而，关于受影响女性的妊娠并发症和再生妊娠结果以及GNRH-A-Uposated儿童的神经发育结果几乎熟知。回顾性分析用于在过去17岁时在怀孕期间自然怀孕期间接受Gnrh-A的114名妇女的自然概念后确定产科和再妊再位结果。评估GNRH-A暴露的儿童以确定其新生儿特征和长期神经发育结果。结果与相关年龄匹配对照组的结果进行了比较。六十五名女性有66名活产。新生儿健康结果和母体并发症的发病率在GNRH-A曝光和对照组中相似。三十一岁的GNRH-A-Updosed儿童2-8岁，可用于调查神经发育。除了一个自闭症谱系障碍的情况外，全规模的智能商量得分在正常范围内，类似于对照组的情况。随后，大多数母亲都有成功的怀孕和大约三分之一的女性，随后能够再次进行自然设想。推荐IVF用于患有异位妊娠的女性的再妊娠。怀孕早期暴露于GnRH-A可能是安全的。应考虑到以前GNRH-A暴露的自发性妊娠的结果进行再生的生殖处理建议。

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