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首页> 外文期刊>Radiation oncology >Development of clinical application program for radiotherapy induced cancer risk calculation using Monte Carlo engine in volumetric-modulated arc therapy
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Development of clinical application program for radiotherapy induced cancer risk calculation using Monte Carlo engine in volumetric-modulated arc therapy

机译：放射疗法临床应用程序的开发在体积调制电弧疗法中使用Monte Carlo发动机使用Monte Carlo发动机的癌症风险计算

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The purpose of this study is to develop a clinical application program that automatically calculates the effect for secondary cancer risk (SCR) of individual patient. The program was designed based on accurate dose calculations using patient computed tomography (CT) data and Monte Carlo engine. Automated patient-specific evaluation program was configured to calculate SCR. The application program is designed to re-calculate the beam sequence of treatment plan using the Monte Carlo engine and patient CT data, so it is possible to accurately calculate and evaluate scatter and leakage radiation, difficult to calculate in TPS. The Monte Carlo dose calculation system was performed through stoichiometric calibration using patient CT data. The automatic SCR evaluation program in application program created with a MATLAB was set to analyze the results to calculate SCR. The SCR for organ of patient was calculated based on Biological Effects of Ionizing Radiation (BEIR) VII models. The program is designed to sequentially calculate organ equivalent dose (OED), excess absolute risk (EAR), excess relative risk (ERR), and the lifetime attributable risk (LAR) in consideration of 3D dose distribution analysis. In order to confirm the usefulness of the developed clinical application program, the result values from clinical application program were compared with the manual calculation method used in the previous study. The OED values calculated in program were calculated to be at most approximately 13.3% higher than results in TPS. The SCR result calculated by the developed clinical application program showed a maximum difference of 1.24% compared to the result of the conventional manual calculation method. And it was confirmed that EAR, ERR and LAR values can be easily calculated by changing the biological parameters. We have developed a patient-specific SCR evaluation program that can be used conveniently in the clinic. The program consists of a Monte Carlo dose calculation system for accurate calculation of scatter and leakage radiation and a patient-specific automatic SCR evaluation program using 3D dose distribution. The clinical application program that improved the disadvantages of the existing process can be used as an index for evaluating a patient treatment plan.
机译：本研究的目的是开发一种临床应用程序，可自动计算个体患者的二次癌症风险（SCR）的效果。该程序是根据使用患者计算机断层扫描（CT）数据和蒙特卡罗发动机的准确剂量计算而设计的。自动患者特定的评估程序配置为计算SCR。应用程序旨在使用Monte Carlo发动机和患者CT数据重新计算治疗计划的光束序列，因此可以精确地计算和评估散射和泄漏辐射，难以在TPS中计算。使用患者CT数据通过化学计量校准进行蒙特卡罗剂量计算系统。使用MATLAB创建的应用程序中的自动SCR评估程序被设置为分析结果以计算SCR。基于电离辐射（BEIR）VII模型的生物学效应来计算患者器官的SCR。该程序旨在顺序地计算器官等效剂量（OED），过度的绝对风险（耳），考虑到3D剂量分布分析，以及寿命可归因的风险（LAR）。为了确认发达的临床应用程序的有用性，将临床应用程序的结果值与前一项研究中使用的手动计算方法进行比较。在程序中计算的OED值计算为比TPS中的结果高出大约13.3％。由开发的临床应用程序计算的SCR结果显示出与传统手动计算方法的结果相比的最大差为1.24％。并且证实了耳朵，错误和LAR值可以通过改变生物参数来容易地计算。我们开发了一种特定于患者的SCR评估程序，可以在诊所方便地使用。该程序包括蒙特卡罗剂量计算系统，用于准确计算散射和泄漏辐射和使用3D剂量分布的患者特异性自动SCR评估程序。改善现有方法缺点的临床应用程序可以用作评估患者治疗计划的指标。

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