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Assessing the impact of a restrictive opioid prescribing law in West Virginia

机译:评估弗吉尼亚州西弗吉尼亚州的限制性阿片规定法的影响

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The Opioid Reduction Act (SB 273) took effect in West Virginia in June 2018. This legislation limited ongoing chronic opioid prescriptions to 30?days’ supply, and first-time opioid prescriptions to 7?days’ supply for surgeons and 3?days’ for emergency rooms and dentists. The purpose of this study was to determine the effect of this legislation on reducing opioid prescriptions in West Virginia, with the goal of informing future similar policy efforts. Data were requested from the state Prescription Drug Monitoring Program (PDMP) including overall number of opioid prescriptions, number of first-time opioid prescriptions, average daily morphine milligram equivalents (MME) and prescription duration (expressed as “days’ supply”) given to adults during the 64?week time periods before and after legislation enactment. Statistical analysis was done utilizing an autoregressive integrated moving average (ARIMA) interrupted time series analysis to assess impact of both legislation announcement and enactment while controlling secular trends and considering autocorrelation trends. Benzodiazepine prescriptions were utilized as a control. Our analysis demonstrates a significant decrease in overall state opioid prescribing as well as a small change in average daily MME associated with the date of the legislation’s enactment when considering serial correlation in the time series and accounting for pre-intervention trends. There was no such association found with benzodiazepine prescriptions. Results of the current study suggest that SB 273 was associated with an average 22.1% decrease of overall opioid prescriptions and a small change in average daily MME relative to the date of legislative implementation in West Virginia. There was, however, no association of the legislation on first-time opioid prescriptions or days’ supply of opioid medication, and all variables were trending downward prior to implementation of SB 273. The control demonstrated no relationship to the law.
机译:Apioid减少法案(SB 273)于2018年6月在西弗吉尼亚效应生效。该立法有限公司有限于慢性阿片类药物前往30?天的供应,以及首次表阿片类药物的外科医生和3天的供应急诊室和牙医。本研究的目的是确定该立法对减少西弗吉尼亚州的阿片类药物处方的影响,目标是告知未来类似的政策努力。从州处方药监测计划(PDMP)要求数据,包括阿片类药物处方的总数,首次阿片类药物处方数量,平均每日吗啡毫克等当量(MME)和处方持续时间(表示为“日元”)给予成人在64个?一周时间段在立法制定之前和之后。利用自回归综合移动平均(Arima)中断时间序列分析进行统计分析,以评估立法公告和制定的影响,同时控制世俗趋势,考虑自相关趋势。苯二氮卓前处方用作对照。我们的分析表明整体国家阿片类药物规定的显着降低以及在考虑时间序列中的串行相关性和核算前趋势趋势时,与立法颁布日期相关的平均每日MME的小变化。没有苯并二氮杂卓的处方发现这种关联。目前的研究结果表明,SB 273与平均联系22.1%的综合体处方减少,平均每日MME的较小变化相对于西弗吉尼亚州的立法实施日期。但是,没有关于首次阿片类药物处方或数天的阿片类药物供应的立法的关联,并且在执行SB 273之前,所有变量都在向下培训。该控制证明没有与法律的关系。

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