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Sero-epidemiology of human coronaviruses in three rural communities in Ghana

机译：加纳三农村社区人冠状病病毒的血清流行病学

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Introduction: acute respiratory tract infections (ARIs) are responsible for significant proportions of illnesses and deaths annually. Most of ARIs are of viral etiology, with human coronaviruses (HCoVs) playing a key role. This study was conducted prior to the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to provide evidence about the sero-epidemiology of HCoVs in rural areas of Ghana. Methods: this was a crosssectional study conducted as part of a large epidemiological study investigating the occurrence of respiratory viruses in 3 rural areas of Ghana; Buoyem, Kwamang and Forikrom. Serum samples were collected and tested for the presence of IgGantibodies to three HCoVs; HCoV-229E, HCoVOC43 and HCoV-NL63 using immunofluorescence assay. Results: of 201 subjects enrolled into the study, 97 (48.3%) were positive for all three viruses. The most prevalent virus was HCoV-229E (23%; 95% CI: 17.2 - 29.3), followed by HCoV-OC43 (17%; 95% CI: 12.4 - 23.4), then HCoV-NL63 (8%, 95% CI: 4.6 - 12.6). Subjects in Kwamang had the highest sero-prevalence for HCoV-NL63 (68.8%). human coronaviruses-229E (41.3%) and HCoVOC43 (45.7%) were much higher in Forikrom compared to the other study areas. There was however no statistical difference between place of origin and HCoVs positivity. Although blood group O and B were most common among the recruited subjects, there was no significant association (p = 0.163) between blood group and HCoV infection. Conclusion: this study reports a 48.3% sero-prevalence of HCoVs (OC43, NL63 and 229E) among rural communities in Ghana. The findings provide useful baseline data that could inform further sero-epidemiological studies on SARS-CoV-2 in Africa.
机译：简介：急性呼吸道感染（ARIS）每年都有大量的疾病和死亡。 aris的大部分是病毒性病因，人冠状病毒（hcovs）发挥关键作用。本研究在爆发严重急性呼吸综合征Coronavirus-2（SARS-COV-2）之前进行，以提供有关加纳农村地区HCOV的血清流行病学的证据。方法：这是作为大型流行病学研究的一部分进行的次译研究，调查加纳3个农村地区呼吸道病毒的发生;福伊姆，kwamang和forikrom。收集并测试血清样品并测试Iggantibodies至三个Hcovs; HCoV-229E，HCOVOC43和HCOV-N163使用免疫荧光测定。结果：201人读入研究的科目，97例（48.3％）对所有三种病毒为阳性。最流行的病毒是HCOV-229E（23％; 95％CI：17.2-29.3），其次是HCOV-OC43（17％; 95％CI：12.4 - 23.4），然后HCOV-N163（8％，95％CI） ：4.6 - 12.6）。 KWAMANG的受试者对HCOV-NL63（68.8％）的血清流行最高。与其他研究区相比，人冠状病毒-229e（41.3％）和Hcovoc43（45.7％）在Forikrom中高得多。然而，原产地和HCOVS阳性之间没有统计学差异。虽然血液组o和b在募集受试者中最常见，但血型和hcov感染之间没有显着的关联（p = 0.163）。结论：本研究报告了加纳农村社区中HCOVS（OC43，NL63和229E）的48.3％血清患病率。该研究结果提供了有用的基线数据，可以为非洲的SARS-COV-2提供进一步的血清流行病学研究。

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