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首页> 外文期刊>Trials >The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement
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The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement

机译：第一次发作精神病（EYE-2）研究中的早期青年参与研究：务实的集群随机控制的实施，有效性和成本效益的基于团队的动机参与干预，以提高参与

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Early Intervention in Psychosis (EIP) services improve health outcomes for young people with psychosis in the medium–long term, but 25% of young people disengage in the first 12?months with costs to their mental health, families, society and the NHS. This study will evaluate the effectiveness, cost-effectiveness and implementation of a team-based motivational Early Youth Engagement (EYE-2) intervention. The study design is a cluster randomised controlled trial (RCT) with economic evaluation, comparing the EYE-2 intervention standardised EIP service to standardised EIP service alone, with randomisation at the team level. A process evaluation will evaluate the delivery of the intervention qualitatively and quantitatively across contexts. The setting is 20 EIP teams in 5 sites: Manchester, South London, East Anglia, Thames Valley and Hampshire. Participants are young people (14–35?years) with first episode psychosis, and EIP staff. The intervention is the team-based motivational engagement (EYE-2) intervention, delivered alongside standardised EIP services, and supported by additional training, website, booklets and social groups. The comparator is the standardised EIP service. Both interventions are delivered by EIP clinicians. The primary outcome is time to disengagement (time in days from date of allocation to care coordinator to date of last contact following refusal to engage with EIP service, or lack of response to EIP contact for a consecutive 3-month period). Secondary outcomes include mental and physical health, deaths, social and occupational function, recovery, satisfaction and service use at 6, 12, 18 and 24?months. A 12-month within-trial economic evaluation will investigate cost-effectiveness from a societal perspective and from an NHS perspective. The trial will provide the first test of an engagement intervention in standardised care, with the potential for significant impact on the mental health and wellbeing of young people and their families, and economic benefits for services. The intervention will be highly scalable, supported by the toolkit including manuals, commissioning guide, training and resources, adapted to meet the needs of the diverse EIP population, and based on an in-depth process evaluation. ISRCTN 51629746 prospectively registered 7th May 2019. Date assigned 10th May 2019.
机译：早期干预精神病（EIP）服务在中长期内为青少年的青少年改善了健康结果，但25％的年轻人在前12个月内脱离，他们的心理健康，家庭，社会和NHS成本。本研究将评估基于团队的激励早期青年参与（EYE-2）干预的有效性，成本效益和实施。该研究设计是一个集群随机对照试验（RCT），具有经济评估，将Eye-2干预标准化EIP服务与标准化的EIP服务相比，在团队层面随机化。过程评估将评估定性和定量跨越上下文的干预的交付。该设置是5个地点的20个EIP团队：曼彻斯特，南伦敦，东安格利亚，泰晤士河谷和汉普郡。参与者是年轻人（14-35岁），第一集精神病和EIP工作人员。干预是基于团队的动机参与（Eye-2）干预，与标准化的EIP服务一起交付，并由其他培训，网站，小册子和社会群体提供支持。比较器是标准化的EIP服务。两种干预措施都由EIP临床医生提供。主要结果是脱离的时间（在拒绝与EIP服务中拒绝与EIP服务签署拒绝与EIP服务签订的最后一份联系日期到日期的时间从分配日期到期的时间，或者在连续的3个月内缺乏EIP联系方式）。二次结果包括6,12,18和24个月的精神和身体健康，死亡，社会和职业功能，恢复，满意度和服务使用。审判内部经济评估中的12个月将从社会视角和NHS角度调查成本效益。该审判将在标准化护理中提供参与干预的第一次测试，具有对年轻人及其家庭的心理健康和福祉的重大影响以及服务的经济效益。该干预将是高度可扩展的，由工具包提供支持，包括手册，调试指南，培训和资源，适用于满足不同EIP人群的需求，并基于深入的过程评估。 ISRCTN 51629746 2019年5月7日预期注册。2019年5月10日分配的日期。

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