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首页> 外文期刊>Journal of Clinical Sciences >Gastrointestinal stromal tumor experience in a surgical oncological unit in sub-Saharan Africa: A retrospective analysis
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Gastrointestinal stromal tumor experience in a surgical oncological unit in sub-Saharan Africa: A retrospective analysis

机译：撒哈拉以南非洲外科肿瘤系统中的胃肠道质量肿瘤经验：回顾性分析

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Background: Gastrointestinal stromal tumors (GISTs) are characterized by specific immunohistochemical and genetic features. This study investigated the clinicopathologic features and surgical outcomes of 54 patients with GIST in a major referral hospital in sub-Sahara Africa. Methods: This retrospective cross-sectional single-center study describes 54 patients who underwent surgery for GIST between 1999 and 2019 in a Nigerian Tertiary Hospital. All cases were confirmed by immunohistochemistry and were analyzed for clinical characteristics, clinical management, and histopathologic data. The risk of recurrence was determined using the Fletcher National Institutes of Health criteria. Results: The mean age of the patients was 57.6 years ± 15.3 (11–81 years), and most patients (67%) underwent abdominal computed tomography scans preoperatively. The most common presentation was an abdominal mass (48%). The stomach was the most common site of GIST (37%). The mean tumor size was 8.9 cm (5–18 cm), and tumor morphology showed spindle cell type (75.9%), mixed spindled-epithelioid (20.3%), and epithelioid (3.7%) cell types. Overall, 51% had a high risk for recurrence. Conclusion: The clinicopathologic features of GIST in this study are consistent with reports in the literature. Slight variations in risk profile may be due to late presentation in our settings.
机译：背景：胃肠道间质瘤（GIST）的特征在于特异性免疫组织化学和遗传特征。本研究调查了在撒哈拉非洲主要推荐医院的54例GIST临床病理特征和手术结果。方法：该回顾性横截面单中心研究描述了54名接受1999年至2019年尼日利亚高等教育医院的GIST手术的患者。所有病例均通过免疫组织化学证实，分析临床特征，临床管理和组织病理数据。使用弗莱彻国家卫生标准确定复发风险。结果：患者的平均年龄为57.6岁±15.3（11-81岁），大多数患者（67％）术前腹部计算断层扫描。最常见的呈现是腹部（48％）。胃是GIST中最常见的网站（37％）。平均肿瘤大小为8.9厘米（5-18厘米），肿瘤形态显示主轴电池型（75.9％），混合的纺织上皮（20.3％）和上皮内（3.7％）细胞类型。总体而言，51％的复发风险很高。结论：本研究中GIST的临床病理特征与文献中的报道一致。风险概况的略有变化可能是由于我们的设置中的后期呈现。

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