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首页> 外文期刊>Journal of Clinical Sciences >Surrogate markers and predictors of insulin resistance in Nigeria patients with Type 2 diabetes mellitus: A cross sectional study
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Surrogate markers and predictors of insulin resistance in Nigeria patients with Type 2 diabetes mellitus: A cross sectional study

机译：尼日利亚患者2型糖尿病患者胰岛素抵抗的替代标记和预测因子：横截面研究

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Background: This study set out to identify and compare surrogate markers of insulin resistance (IR) in males and females and compare the prevalence of IR using different surrogate markers. Methods: The study was an analytical cross-sectional hospital-based study among Nigerians with Type 2 diabetes mellitus (T2DM). A total of 234 (131 T2DM and 103 healthy) persons were invited to participate in the study. One hundred and ninety-nine persons completed the study. The following anthropometric measurements were taken (height [m], weight [kg], waist circumference [cm], and hip circumference [cm]). IR score (IRS) was derived using these six measurements: fasting basal insulin, fasting C-peptide, glucose-insulin ratio, quantitative insulin sensitivity check index, homeostasis model assessment (HOMA-IR), HOMA-c-peptide. Results: Using an IRS of 11 as criteria for IR, 52 (41.6%) of T2DM, and 21 (28.4%) of the control group were found to have IR. Forty-five percent of the DM females and 36.4% of DM males had IR, respectively, whereas 31.8% of the control females and 23.3% of control males had IR, respectively. Visceral Adiposity Index (VAI) had the best predictive value with the highest area under the receiver operating characteristic curve (0.648). Conclusion: The prevalence of IR is nonsignificantly higher in females than males. VAI is the best surrogate marker to predict the presence of IR among the male study participants, while waist circumference is the best surrogate marker to predict the presence of IR among the female study participants.
机译：背景：本研究阐述了鉴定和比较男性和女性的胰岛素抵抗（IR）的替代标志物，并比较IR使用不同替代标志物的患病率。方法：该研究是尼日利亚人的分析横截面医院的研究，具有2型糖尿病（T2DM）。邀请共有234名（131至T2DM和103名健康）人参加该研究。一百九十九人完成了这项研究。取出以下人体测量测量（高度[m]，重量[kg]，腰围[cm]和臀周长[cm]）。使用这六次测量来源的IR分数（IRS）：禁食基底胰岛素，禁食C-肽，葡萄糖 - 胰岛素比，定量胰岛素敏感性检查指数，稳态模型评估（HOMA-IR），HOMA-C-肽。结果：使用IRS的IRS＆GT; 11作为IR的标准，52（41.6％）T2DM，21（28.4％）的对照组有IR。 45％的DM女性和36.4％的DM男性分别具有IR，而31.8％的控制女性和23.3％的对照男性分别具有IR。内脏肥胖指数（VAI）具有最佳的预测值，在接收器下的最高面积下的接收器操作特征曲线（0.648）。结论：女性的IR患病率比男性在一起。 vai是预测男性研究参与者中IR中的最佳替代标记，而腰围是预测女性研究参与者中IR的存在的最佳替代标记。

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