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首页> 外文期刊>Journal of clinical laboratory analysis. >A renewed understanding of anti‐human globulin reagents: interference constraints using an optimization method in pretransfusion compatibility tests
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A renewed understanding of anti‐human globulin reagents: interference constraints using an optimization method in pretransfusion compatibility tests

机译：重新对抗人球蛋白试剂的理解：使用优化方法在预去回兼容性测试中的干扰约束

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摘要

Anti‐human globulin (AHG) reagents are widely applied in pretransfusion compatibility tests. The accuracy of detection with AHG reagents is mainly affected by irregular antibodies or cold agglutinins in blood samples, which are related to the human complement system. Although much has been written about various types and applications of AHG reagents, their characteristics, interference factors and optimal selection in pretransfusion compatibility tests still need to be further clarified. Here, we review clinical practice and basic studies that describe each AHG reagent, summarize the advantages and disadvantages of using different AHG reagents in the presence of cold agglutinins or complement‐fixing antibodies, explore the potential mechanisms by which the complement system influences detection with AHG reagents and address the question of how to optimally select AHG reagents for clinically significant antibody detection.
机译：抗人球蛋白（AHG）试剂广泛应用于预转移相容性试验中。 用AHG试剂检测的准确性主要受血液样品中的不规则抗体或冷凝集素的影响，血液样本中与人类补体系统有关。 虽然已经写了很多关于AHG试剂的各种类型和应用，但他们的特征，干扰因子和在预去回兼容性测试中的最佳选择仍然需要进一步阐明。 在这里，我们审查描述每个AHG试剂的临床实践和基本研究，总结使用不同AHG试剂在冷凝集蛋白或补体固定抗体存在下使用不同的AHG试剂的缺点，探讨了补体系统对AHG进行检测的潜在机制 试剂并解决如何在临床上选择AHG试剂的问题，用于临床上显着的抗体检测。

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