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首页> 外文期刊>Journal of experimental & clinical cancer research : >Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis
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Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis

机译：目前乳腺癌微环境通过单细胞分析的综合描述

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Breast cancer is a heterogeneous disease with a complex microenvironment consisting of tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells shape the tumor microenvironment (TME) and influence the progression of breast cancer and the therapeutic responses in patients. The exact composition of the intra-tumoral cells is mixed as the highly heterogeneous and dynamic nature of the TME. Recent advances in single-cell technologies such as single-cell DNA sequencing (scDNA-seq), single-cell RNA sequencing (scRNA-seq) and mass cytometry have provided new insights into the phenotypic and functional diversity of tumor-infiltrating cells in breast cancer. In this review, we have outlined the recent progress in single-cell characterization of breast tumor ecosystems, and summarized the phenotypic diversity of intra-tumoral cells and their potential prognostic relevance.
机译：乳腺癌是一种异质疾病，具有由肿瘤细胞，免疫细胞，成纤维细胞和血管细胞组成的复杂的微环境。 这些癌症相关细胞塑造肿瘤微环境（TME）并影响乳腺癌的进展和患者治疗反应。 肿瘤内细胞的确切组成作为TME的高度异质和动态性质。 单细胞技术（如单细胞DNA测序（SCDNA-SEQ），单细胞RNA测序（SCRNA-SEQ）和质量细胞学中的最新进展已经为乳腺渗透细胞的表型和功能多样性提供了新的见解 癌症。 在本综述中，我们概述了乳腺肿瘤生态系统的单细胞表征的最近进展，并概括了肿瘤内细胞的表型多样性及其潜在的预后相关性。

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