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首页> 外文期刊>Journal of the Canadian Association of Gastroenterology >THE RISING GLOBAL INCIDENCE OF PEDIATRIC INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW OF POPULATION-BASED STUDIES
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THE RISING GLOBAL INCIDENCE OF PEDIATRIC INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW OF POPULATION-BASED STUDIES

机译：儿科炎症性肠病的全球发病率升高：对基于人口的研究进行了系统综述

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Background The incidence of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is increasing internationally, particularly in developing nations where rates were historically low. Previous reports of the incidence and prevalence of pediatric-onset IBD have identified a paucity of population-based studies. Aims We reviewed the global trends in incidence of pediatric IBD using evidence from population-based studies. Methods (PROSPERO CRD42019125193) We systematically reviewed studies indexed in MEDLINE, EMBASE, Airiti Library, and SciELO from 01/2010-02/2020 to identify population-based studies reporting the incidence of pediatric-onset IBD, CD, and UC. Included studies combined childhood and adolescent-onset IBD (onset 21y). Changes in incidence since 2000 were plotted by continent, with data from 2000–09 provided by our previous systematic review 1 . To depict trends, multiple times points reported in single studies were connected on graphs. When incidence was reported as an aggregated estimate over a range of years, data was plotted using the midpoint of the interval. Results Of 8096 abstracts screened, 74 studies described the incidence of IBD, CD, or UC in 33 countries (Figure panel A). The incidence of pediatric-onset IBD is highest in Northern Europe and North America, and lowest in Southern Europe, Asia, and the Middle East. This geographical distribution is similar in UC, while incidence of pediatric-onset CD is highest in North America and Northern Europe, followed by Australia. Trends in incidence over time, stratified by continent, are reported in Figure, panel B. Significantly increasing incidence of IBD, CD, and/or UC was reported in China, Bahrain, Canada, New Zealand, Australia, Singapore, Saudi Arabia, and most European countries. Very Early Onset (VEO) IBD significantly increased in Canada, however Saudi Arabia reported decreasing incidence of VEO-CD but stable incidence of VEO-UC. Conclusions Conclusion: Incidence of pediatric-onset IBD are highest in Northern Europe and North American and are increasing globally. There remains a paucity of studies from many parts of the world on the incidence pediatric IBD. Further research is needed to understand the pathogenesis of the rising incidence of pediatric IBD, including work to understand the genetic, environmental, immunological and microbiome alterations leading to the increasing rates in children.References: 1 Benchimol, Fortinsky et al. Inflamm Bowel Dis 2011;17:423–39. Open in new tab Download slide Figure. (A) Geographic variation in incidence of pediatric IBD. (B) Temporal trends of pediatric IBD, with each continent represented by line colour. Open in new tab Download slide Figure. (A) Geographic variation in incidence of pediatric IBD. (B) Temporal trends of pediatric IBD, with each continent represented by line colour.
机译：背景技术炎症性肠病（IBD）的发病率（包括CrOHN疾病（CD）和溃疡性结肠炎（UC）在国际上正在增加，特别是在发展中国家历史上的发展中国家。前一篇关于儿科发病IBD的发病率和患病率的报道已经确定了缺乏基于人群的研究。旨在使用基于人口的研究的证据审查了儿科IBD发病率的全球趋势。方法（Prospero CRD42019125193）我们系统地审查了01/2010-02 / 2020中的Medline，Embase，Airiti图书馆和Scielo中指标的研究，以确定报告基于人群的研究，报告儿科发病IBD，CD和UC的发生率。包括研究组合儿童和青少年 - 发作IBD（发病＆lt 210）。自2000年以来的发病率变化由大陆绘制，数据来自2000 - 09年度，我们以前的系统审查提供1。为了描绘趋势，在图形上连接了单一研究中报告的多次点。当报告发病率为一段时间的汇总估计时，使用间隔的中点绘制数据。结果8096摘要筛选，74项研究描述了33个国家IBD，CD或UC的发生率（图专家组A）。欧洲北部和北美的儿科发病IBD的发病率最高，南欧，亚洲和中东最低。这种地理分布在UC中类似，而北美和北欧的儿科发病CD的发病率最高，其次是澳大利亚。由大陆分层的发生率的发病率趋势在图中报告，Panel B.在中国，巴林，加拿大，新西兰，澳大利亚，新加坡，沙特阿拉伯和和大多数欧洲国家。早期发病（VEO）IBD在加拿大显着增加，但沙特阿拉伯报告了Veo-CD的发病率降低，但稳定的Veo-UC发病率。结论结论：北欧北部和北美的儿科发病IBD的发病率在全球范围内增加。仍然缺乏来自世界许多地区的入学儿科IBD的研究。需要进一步的研究来了解儿科IBD的发病率的发病机制，包括了解导致儿童速度增加的遗传，环境，免疫学和微生物组改变的工作。参考要求：1个Benchimol，Fortinsky等。 Innamame Beel Dis 2011; 17：423-39。在新选项卡中打开下载幻灯片图。 （a）儿科IBD发病率的地理变异。 （b）儿科IBD的时间趋势，每个大陆由线颜色代表。在新选项卡中打开下载幻灯片图。 （a）儿科IBD发病率的地理变异。 （b）儿科IBD的时间趋势，每个大陆由线颜色代表。

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