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首页> 外文期刊>BMC Cancer >Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones
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Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones

机译：雌性肺癌风险和性类固醇激素的关联：对内源性和外源性类性甾醇的全球流行病学证据进行系统审查和荟萃分析

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Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure specifically on the risk of lung cancer in women. The PubMed, MEDLINE, Web of Science, and EMBASE databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for female lung cancer risk associated with sex steroid hormones were calculated overall and by study design, publication year, population, and smoking status. Sensitivity analysis, publication bias, and subgroup analysis were performed. Forty-eight studies published between 1987 and 2019 were included in the study with a total of 31,592 female lung cancer cases and 1,416,320 subjects without lung cancer. Overall, higher levels of sex steroid hormones, both endogenous (OR: 0.92, 95% CI: 0.87–0.98) and exogenous (OR: 0.86, 95% CI: 0.80–0.93), significantly decreased the risk of female lung cancer by 10% (OR: 0.90, 95% CI: 0.86–0.95). The risk of lung cancer decreased more significantly with a higher level of sex steroid hormones in non-smoking women (OR: 0.88, 95% CI: 0.78–0.99) than in smoking women (OR: 0.98, 95% CI: 0.77–1.03), especially in Asia women (OR: 0.84, 95% CI: 0.74–0.96). Our meta-analysis reveals an association between higher levels of sex steroid hormone exposure and the decreased risk of female lung cancer. Surveillance of sex steroid hormones might be used for identifying populations at high risk for lung cancer, especially among non-smoking women.
机译：已发表的研究结果表明肺癌风险的性差异以及性类固醇激素的潜在作用。我们的目标是进行荟萃分析，以探讨性类固醇激素暴露的影响，特别是女性肺癌风险。搜索了PubMed，Medline，Science和Embase数据库。汇集的赔率比（ORS）和95％的置信区间（或95％CIS）总体而言，通过研究设计，出版年度，人口和吸烟地位计算了与性类固醇激素相关的雌性肺癌风险。进行敏感性分析，出版物偏见和亚组分析。 1987年至2019年间公布的四十八项研究纳入该研究中，共有31,592名雌性肺癌病例和1,416,320名受试者，没有肺癌。总体而言，更高水平的性类固醇激素，内源性（或：0.92,95％CI：0.87-0.98）和外源（或：0.86,95％CI：0.80-0.93），大大降低了10次雌性肺癌的风险％（或：0.90,95％CI：0.86-0.95）。肺癌的风险比吸烟妇女更高水平的性类固醇激素（或：0.88,95％：0.78-0.99）比吸烟妇女（或0.98,95％：0.77-1.03 ），特别是在亚洲女性（或：0.84,95％CI：0.74-0.96）。我们的荟萃分析揭示了更高水平的性类固醇激素暴露和雌性肺癌风险降低的关联。性类固醇激素的监测可用于鉴定肺癌的高风险的群体，特别是在非吸烟妇女中。

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