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首页> 外文期刊>Cureus. >Acute Hepatitis and Pancytopenia in a Child With Chronic Abuse of Senna
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Acute Hepatitis and Pancytopenia in a Child With Chronic Abuse of Senna

机译：急性肝炎和胰腺炎患者在一个患有森纳的儿童

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Long-term use of Senna and its anthraquinone glycosides has been associated with the development of hepatotoxicity in both children and adults. Our case study aims to present, for the first time, acute hepatitis associated with pancytopenia in relation probably to liver and bone marrow toxicity in a three-year-old child suffering from chronic abuse of Senna. We report the case of a three-year-old girl with a history of chronic constipation regularly treated with drinkable preparations made from the Senna plant and hospitalized eight months ago with an almost similar and reversible clinical presentation, probably of toxic origin. She was admitted to a pediatric intensive care unit with severe acute hepatitis and profound pancytopenia. Her first physical examination revealed an unconscious child with a Glasgow score of 11/15, generalized hypotonia, bleeding from the gum lining, facial erythrosis with peeling cheeks, hair loss (telogen effluvium), erythematous lesions ulcers of the anal margin, and fever. The myelogram performed two days after admission?revealed a rich regenerative bone marrow with signs of inflammation. Besides, she developed deep vein thrombosis three days after placing her femoral catheter. Pancytopenia in hospitalized children is a rare but alarming situation. In our case, malignancy was excluded, as well as a severe infection. The cause of pancytopenia could be related to the toxic effects of Senna. Chronic use of Senna may be associated with bone marrow and liver toxicity and lead to deep vein thrombosis.
机译：长期使用塞纳及其蒽醌糖苷与儿童和成年人的肝毒性发育有关。我们的案例研究旨在第一次出现急性肝炎，这可能在一个患有患有长期虐待森纳的三岁儿童中的肝脏和骨髓毒性相关。我们举报了一个三岁的女孩，一个三岁的女孩，经常用塞纳植物和八个月前住院治疗的饮用饮品和住院的饮用制剂，具有几乎相似和可逆的临床介绍，可能是有毒的。她被录取了儿科重症监护病房，具有严重的急性肝炎和深刻的韧皮病。她的第一次体检揭示了一个无意识的孩子，Glasgow得分为11/15，广义肺炎，从牙龈衬里出血，面部赤膜鼻疽，脱胶脸颊，脱发（脑梭菌），红斑病变溃疡的肛门边缘，发烧。米洛奇入学后两天进行？揭示了一种富含炎症的再生骨髓。此外，她在将股骨导管放置后三天开发了深静脉血​​栓形成。住院儿童的Pancytopenia是一种罕见但令人惊叹的情况。在我们的情况下，恶性肿瘤被排除在外，以及严重的感染。韧皮病的原因可能与塞纳的毒性作用有关。患森纳的慢性用途可能与骨髓和肝毒性相关，导致深静脉血栓形成。

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