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首页> 外文期刊>Cureus. >Assessing Consistency of Drug-Drug Interaction-Related Information Across Various Drug Information Resources
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Assessing Consistency of Drug-Drug Interaction-Related Information Across Various Drug Information Resources

机译：评估各种药物信息资源中药物互动相关信息的一致性

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Background Information related to drug-drug interactions (DDIs) varies significantly from one drug information (DI) resource to another. These variations pose challenges for healthcare professionals in making the right decisions regarding using some of the drug combinations in needy patients. The objective of this study was to review?eight different DI resources for scope, completeness, and consistency of information related to DDIs. Methodology A total of eight DI resources, namely, Micromedex ? , Portable Electronic Physician Information Database ? , UpToDate ? , Medscape.com drug interaction checker, Drugs.com drug interaction checker, Stockley’s Drug Interactions?(ninth edition, 2010), Drug Interactions Analysis & Management: Facts and Comparisons 2014 (ninth edition, 2014), and the drug interaction appendix of the British National Formulary-76, were compared. Each DI resource?was?scored for scope by calculating the percentage of interactions that had an entry in each resource. A completeness score was calculated for each resource describing severity, clinical effects, mechanism, and DDI management. The consistency of the information was assessed using Fleiss Kappa (k) score estimated using ReCal3 0.1 (alpha) web service and Statistical Package for the Social Sciences version 24. Results The scope score was the highest (100%) for UpToDate ? and Portable Electronic Physician Information Database ? , whereas the completeness score was the highest (100%) for Drug Interaction Analysis & Management: Facts and comparisons 2014. The inter-source reliability scores among the eight different DI sources were poor (k 0.20, p 0.05) for documentation of information related to severity, clinical effects, mechanism, and management of DDIs. Conclusions Variations in the information cause uncertainty among healthcare professionals concerning interacting drug pairs in clinical practice. This may also increase the possibility of adverse drug outcomes when interacting drug pairs are used in at-risk patients. We recommend comprehensive preventive and management strategies for DDIs depending on a uniform scale of severity and clinical effects across various DI resources.
机译：与药物 - 药物相互作用（DDIS）相关的背景信息从一个药物信息（DI）资源到另一个药物信息（DDIS）有显着变化。这些变化对医疗保健专业人员构成了挑战，以便在有需要的患者中使用一些药物组合进行有关有关一些药物组合的正确决策。本研究的目的是审查？八个不同的DI资源，用于达迪斯有关的信息的范围，完整性和信息一致性。方法总共八个DI资源，即MicroMedex？ ，便携式电子医师信息数据库？ ， 最新 ？ ，Medscape.com药物互动检查员，药物互动检查员，斯托克利的药物互动？（第九版，2010），药物交互分析与管理：事实和比较2014（第九版，2014），以及药物互动附录比较英国国家惯例76。每个DI资源？是？通过计算每个资源中有一个条目的交互百分比来评分范围。针对描述严重程度，临床效果，机制和DDI管理的每个资源计算完整性分数。使用Recal3 0.1（Alpha）Web服务和社会科学版本24的统计包评分评估信息的一致性。结果范围得分是Uptodate的最高（100％）？和便携式电子医师信息数据库？ ，而完整性得分是药物互动分析和管理的最高（100％）：2014年的事实和比较。八种不同的DI源之间的源间可靠性得分差（K <0.20，P <0.05）与DDIS的严重程度，临床效果，机制和管理有关的信息文件。结论在临床实践中涉及互动药物对的医疗保健专业人员的不确定性。当在风险患者中使用互动药物对时，这也可能增加不良药物结果的可能性。我们为DDI建议综合预防和管理战略，具体取决于各种DI资源的统一规模和临床影响。

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