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Calcium-Alkali Syndrome: Historical Review, Pathophysiology and Post-Modern Update

机译:钙碱综合征:历史评论,病理生理学和现代更新

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Milk-alkali syndrome or calcium-alkali syndrome (CAS) is the triad of hypercalcemia, metabolic alkalosis and renal impairment. It is often related to ingestion of high amounts of calcium carbonate, which was used historically for the treatment of peptic ulcer disease. The incidence of the syndrome decreased dramatically after the introduction of newer peptic ulcer medications such as proton pump inhibitors and histamine blocking agents. However, a resurgence was seen in the late 1980s with the wide use of over-the-counter calcium supplements, mainly by females for osteoporosis prophylaxis. The modern version of the syndrome continues to evolve along with medical management. This review focuses on the historical context of CAS, pathogenesis, resurgence of the condition with variable presentations, and contemporary management.
机译:乳碱综合征或钙 - 碱综合征(CAS)是高钙血症,代谢碱中毒和肾损伤的三合会。 它通常与摄入大量碳酸钙有关,这是历史上用于治疗消化性溃疡病的钙质。 在引入新的消化性溃疡药物如质子泵抑制剂和组胺封闭剂之后,综合征的发病率显着降低。 然而,在20世纪80年代后期可以看到重新疗程,广泛使用过度使用的钙补充剂,主要由女性用于骨质疏松症预防。 现代版本的综合症继续与医疗管理一起发展。 本综述重点介绍了CAS,发病机制,病情复苏,可变演示的条件,以及当代管理。

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