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首页> 外文期刊>Cureus. >Diagnostic Accuracy of the Forns Score for Liver Cirrhosis in Patients With Chronic Viral Hepatitis
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Diagnostic Accuracy of the Forns Score for Liver Cirrhosis in Patients With Chronic Viral Hepatitis

机译：慢性病毒性肝炎患者肝硬化福斯血管分数的诊断准确性

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Introduction Liver cirrhosis is an irreversible and end-stage disease. It results from chronic liver damage characterized by the replacement of normal liver tissue by fibrosis, leading to the progressive loss of liver function. Making an early diagnosis of cirrhosis is important for patients with chronic hepatitis because early antiviral therapy can prevent the progression of cirrhosis and even induce regression. There have been efforts to develop surrogate markers for liver cirrhosis as the biopsy is invasive, costly, and difficult to standardize. Methods This was a cross-sectional study conducted at the Section of Chemical Pathology, the Department of Pathology and Laboratory Medicine in Collaboration with the Section of Gastroenterology, Department of Medicine, the Aga Khan University, from January to December 2018.?A total of 90 patients (18 years of age) with a history of chronic viral hepatitis, who were attending the FibroScan? (Echosens, Paris, France) clinic were included. Patients with a history of autoimmune liver diseases and hepatocellular carcinoma were excluded from the study. Blood samples withdrawn were analyzed on ADVIA Centaur ? (Siemens Healthineers,?Erlangen, Germany), and Forns scores were calculated based on the following four parameters: patient?age, total cholesterol, gamma-glutamyl transferase (GGT), and platelet count. Results The median age of the patients was 38.5 years [interquartile range?(IQR): 21]. Among the study population, 59 (65.6%) were males and 31 (34.4%) were females; 26 patients showed reactivity for hepatitis B surface antigen (HBsAg), and 63 patients were found chronic with hepatitis C virus (HCV). The proportion of HCV was observed to be higher as compared with that of?Hepatitis B virus (HBV). Nineteen patients were found to have jaundice and only one patient had ascites. An Area Under the Receiver Operating Curve (AUROC)?was generated to determine the diagnostic accuracy of the Forns score. It was observed that the Forn score value of 7.110 had an AUROC of 0.9928 (95% CI: 0.9821-1.003, p-value: 0.001) with a sensitivity of 100% (95% CI: 91.19-100.0%) and specificity of 94% (95% CI: 83.45-98.75%), with a higher positive likelihood ratio of 16.67. Conclusion This study found the Forns score to be sensitive and specific?in diagnosing liver cirrhosis in patients with chronic hepatitis. The Forns score at a cutoff of 7.11 is highly?sensitive as well as a specific noninvasive method that can be used to ascertain the status of fibrosis in chronic hepatitis patients.
机译：引言肝硬化是一种不可逆转和终末期的疾病。由纤维化替代正常肝组织的慢性肝损伤是慢性肝损伤导致肝功能的慢性病丧失。提前诊断肝硬化对于慢性肝炎患者对于慢性肝炎患者来说是重要的，因为早期的抗病毒治疗可以防止肝硬化进展甚至诱导回归。随着活组织检查侵入性，昂贵，难以标准化，已经努力为肝硬化进行肝硬化的替代标志物。方法是，在2018年1月至12月，在2018年1月至12月，与胃肠内科和实验室医学部门进行化学病理学和实验室医学部门进行的横断面研究。 90名患者（＆ 18岁）患有慢性病毒性肝炎的历史，他正在参加纤维血管？ （呼吸圈，巴黎，法国）诊所被包括在内。研究中排除了具有自身免疫性肝脏疾病和肝细胞癌的患者。在Advia Centaur分析拔出的血液样品？ （西门子Healthineers，？erlangen，德国）和福斯人分数基于以下四个参数来计算：患者？年龄，总胆固醇，γ-谷氨酸转移酶（GGT）和血小板计数。结果患者的中位年龄为38.5岁[四分位数吗？（IQR）：21]。在研究人群中，59名（65.6％）是男性，31例（34.4％）是女性; 26例患者表现出乙型肝炎表面抗原（HBsAg）的反应性，并发现63名患者慢性丙型肝炎病毒（HCV）。观察到HCV的比例与乙型肝炎病毒（HBV）相比更高。九岁患者有黄疸，只有一名患者患有腹水。在接收器操作曲线（AUROC）下的一个区域？被产生以确定福斯斯分数的诊断准确性。观察到＆ 7.110的Forn得分值具有0.9928（95％Ci：0.9821-1.003，P值：<0.001），灵敏度为100％（95％Ci：91.19-100.0％）特异性为94％（95％CI：83.45-98.75％），较高的阳性似然比为16.67。结论本研究发现福斯福斯毒素得分为敏感和特异性？在诊断肝硬化患者慢性肝炎患者中。截止值为7.11的福尔斯福斯福斯福斯福斯福斯福尔斯敏感性和特定的非侵入性方法可用于确定慢性肝炎患者纤维化的状态。

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