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首页> 外文期刊>International journal of infectious diseases : >Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors
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Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors

机译：SARS-COV-2 IgG / IgM抗体的动态变化和患病率：多因素分析

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Objective To investigate the dynamic characteristics of serological antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is of much current significance. Methods The dynamic changes and prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against SARS-CoV-2 were assessed from the time of symptom onset up to 210 days. Antibodies were detected using a chemiluminescence immunoassay. Results The average titers and IgG/IgM positivity rates reached a peak within 30 days of symptom onset and then began to decline continuously. Between 180 and 210 days following symptom onset, the titers of IgG and IgM were 43.1 ± 27.0 AU/mL and 4.4 ± 5.2 AU/mL, respectively, while the respective positivity rates were 84.3% and 12.0%. Further statistical analyses revealed that the dynamic changes and prevalence of the SARS-CoV-2 IgG/IgM antibodies were related to age and disease severity, but not to sex. The dynamic changes and the prevalence were similar for both the IgM and the IgG antibodies. Even so, there was a more rapid rate of decline for the IgM antibodies. It was found that an IgG level of 16.33 ± 3.15 AU/mL may represent a threshold value that should act as an alert, as it may indicate that the IgG level will become undetectable within the next 30–60 days. Conclusion The results provide important information concerning COVID-19 and may be of relevance for diagnosis, treatment, and vaccine development.
机译：目的探讨血清学抗体对严重急性呼吸综合征冠状病毒2（SARS-COV-2）的动态特征，其具有多大的目录意义。方法从症状发病时间开始，评估免疫球蛋白M（IgM）和免疫球蛋白M（IgM）和免疫球蛋白G（IgG）抗体对SARS-COV-2的抗体的动态变化和患病率。使用化学发光免疫测定检测抗体。结果平均滴度和IgG / IgM阳性率在症状发作后30天内达到峰，然后持续下降。在症状发作后180和210天之间，IgG和IgM的滴度分别为43.1±27.0AU / mL和4.4±5.2Au / ml，而各个正率为84.3％和12.0％。进一步的统计分析显示，SARS-COV-2 IgG / IgM抗体的动态变化和患病率与年龄和疾病严重程度有关，但不对性。 IgM和IgG抗体都是相似的动态变化和患病率。即便如此，IgM抗体也更快地下降。结果发现，16.33±3.15 Au / ml的IgG水平可以代表应该充当警报的阈值，因为它可能表明IgG水平在接下来的30-60天内将变得无法察觉。结论结果提供了关于Covid-19的重要信息，可能具有诊断，治疗和疫苗发育的相关信息。

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