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首页> 外文期刊>Bioactive Materials >Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation
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Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation

机译：从骨髓间充质基质细胞衍生自骨髓间充质细胞的工程外来体的移植在电刺激下改善糖尿病周围神经病变

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Diabetic peripheral neuropathy (DPN) is a long-term complication associated with nerve dysfunction and uncontrolled hyperglycemia. In spite of new drug discoveries, development of effective therapy is much needed to cure DPN. Here, we have developed a combinatorial approach to provide biochemical and electrical cues, considered to be important for nerve regeneration. Exosomes derived from bone marrow mesenchymal stromal cells (BMSCs) were fused with polypyrrole nanoparticles (PpyNps) containing liposomes to deliver both the cues in a single delivery vehicle. We developed DPN rat model and injected intramuscularly the fused exosomal system to understand its long-term therapeutic effect. We found that the fused system along with electrical stimulation normalized the nerve conduction velocity (57.60?±?0.45?m/s) and compound muscle action potential (16.96?±?0.73?mV) similar to healthy control (58.53?±?1.10?m/s; 18.19?±?1.45?mV). Gastrocnemius muscle morphology, muscle mass, and integrity were recovered after treatment. Interestingly, we also observed paracrine effect of delivered exosomes in controlling hyperglycemia and loss in body weight and also showed attenuation of damage to the tissues such as the pancreas, kidney, and liver. This work provides a promising effective treatment and also contribute cutting edge therapeutic approach for the treatment of DPN.
机译：糖尿病外周神经病变（DPN）是与神经功能障碍和不受控制的高血糖相关的长期复制。尽管有新的药物发现，但治愈DPN需要有效治疗的发展。在这里，我们开发了一种组合方法来提供生物化学和电气线索，被认为对神经再生是重要的。源自骨髓间充质基质细胞（BMSC）的外泌体与含有脂质体的聚吡咯纳米颗粒（PPYNPS）融合，以在单个递送载体中递送两个提示。我们开发了DPN大鼠模型并注射了肌肉注射的外泌体系统，以了解其长期治疗效果。我们发现融合系统以及电刺激归一化着神经传导速度（57.60？±0.45？m / s）和复合肌动作电位（16.96？±0.73μm≤0.73μmv）（58.53？±1.10 ？M / s; 18.19？±1.45？mV）。治疗后恢复胃肠肌肉形态，肌肉质量和完整性。有趣的是，我们还观察到在控制高血糖和体重损失方面递送外来体的旁碱基效应，并且还显示出对胰腺，肾脏和肝脏等组织损伤的衰减。这项工作提供了有希望的有效处理，也有助于治疗DPN的切削刃治疗方法。

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