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首页> 外文期刊>Cell death discovery. >Molecular mechanism of cell ferroptosis and research progress in regulation of ferroptosis by noncoding RNAs in tumor cells
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Molecular mechanism of cell ferroptosis and research progress in regulation of ferroptosis by noncoding RNAs in tumor cells

机译：肿瘤细胞非分量RNA的细胞裂解体分子机制及研究中的裂解菌调节研究进展

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Ferroptosis is a newly identified form of nonapoptotic regulated cell death characterized by iron-dependent accumulation of lipid reactive oxygen species. Morphologically and biochemically different from known types of cell death and apoptosis, ferroptosis promotes nervous system diseases, renal failure, ischemia–reperfusion injury, and the treatment of tumors. It could be induced by several mechanisms, including inhibition of glutathione peroxidase 4, lack of cysteine, and peroxidation of polyunsaturated fatty acids, but could be inhibited by iron chelators, lipophilic antioxidants, and some specific inhibitors. Ferroptosis is found to be closely related to the tumorigenesis, invasion, and metastasis of tumors. Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), microRNAs, and circular RNAs, do not encode proteins. NcRNAs are found to be capable of regulating the molecular mechanism of ferroptosis in tumor cells post transcription. Ferroptosis provides a new method for cancer treatment. Although several studies have confirmed the important role of ferroptosis in cancer treatment, its specific affecting mechanism is unclear. Here we reviewed the molecular mechanism of ferroptosis in tumor cells and the relationship between ferroptosis and the three important ncRNAs.
机译：恶性凋亡是一种新鉴定的非血症调节细胞死亡形式，其特征在于脂质活性氧的铁依赖性积累。与已知类型的细胞死亡和细胞凋亡的形态学和生物化学不同，裂解球促进神经系统疾病，肾衰竭，缺血再灌注损伤和治疗肿瘤。它可以由几种机制诱导，包括抑制谷胱甘肽过氧化物酶4，缺乏半胱氨酸，以及多不饱和脂肪酸的过氧化，但可以被铁螯合剂，亲脂性抗氧化剂和一些特异性抑制剂抑制。发现脱裂病变与肿瘤的肿瘤内酯，侵袭和转移密切相关。非编码RNA（NCRNA），包括长的非编码RNA（LNCRNA），MicroRNA和圆形RNA，不编码蛋白质。发现NCRNA能够调节转录后肿瘤细胞中的恶性腺炎的分子机制。 Ferr凋亡为癌症治疗提供了一种新方法。虽然有几项研究证实了铁凋亡在癌症治疗中的重要作用，但其特异性的影响机制尚不清楚。在这里，我们审查了肿瘤细胞中的恶性腺炎的分子机制以及裂解子和三个重要NCRNA之间的关系。

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