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首页> 外文期刊>Coatings >Zn-Doped CaP-Based Coatings on Ti–6Al–4V and Ti–6Al–7Nb Alloys Prepared by Magnetron Sputtering: Controllable Biodegradation, Bacteriostatic, and Osteogenic Activities
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Zn-Doped CaP-Based Coatings on Ti–6Al–4V and Ti–6Al–7Nb Alloys Prepared by Magnetron Sputtering: Controllable Biodegradation, Bacteriostatic, and Osteogenic Activities

机译：通过磁控溅射制备的Ti-6Al-4V和Ti-6AL-7NB合金的Zn掺杂的帽涂层：可控的生物降解，抑菌和骨质发生活性

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New TiNb-based alloys, such as Ti–6Al–7Nb, are currently being studied around the world as an alternative to other Ti alloys, e.g., instead of Ti–6Al–4V. We conducted a pilot study where thin (approximately 1.2 micron) CaP coatings containing low doses of Zn2 (0.4–0.8 wt.%) were prepared by the radio frequency magnetron sputtering (RFMS) of Zn-hydroxyapatite (HA) target on Ti–6Al–4V and Ti–6Al–7Nb substrates and investigated their physicochemical properties, in vitro solubility, cytotoxicity, and antibacterial and osteogenic activities. The thickness of the obtained coatings was approximately 1.2–1.3 microns. Zn substitution did not result in roughness or structural or surface changes in the amorphous CaP coatings. The distributions of Ca, P, and Zn were homogeneous across the film thickness as shown by the EDX mapping of these elements. Zn doping of CaP coatings on both types of Ti-based alloys statistically influenced the results of the scratch-test. However, obtained values are satisfactory to use Zn-CaP coatings on biomedical implants. Increased Zn2 release vs. tapered output of Ca and phosphate ions occurred during 5 weeks of an in vitro immersion test in 0.9% NaCl solution. Ti–6Al–7Nb alloy, unlike Ti–6Al–4V, promoted more linear biodegradation of CaP coatings in vitro. As a result, CaP-based surfaces on Ti–6Al–7Nb, compared with on Ti–6Al–4V alloy, augmented the total areas of Alizarin red staining in a 21-day culture of human adipose-derived mesenchymal stem cells in a statistically significant manner. Moreover, Zn–CaP coatings statistically reduced leukemic Jurkat T cell survival within 48 h of in vitro culture. Along with the higher solubility of the Zn–CaP surface, a greater reduction (4- to 5.5-fold) in Staphylococcus aureus growth was observed in vitro when 7-day extracts of the coatings were added into the microbial culture. Hence, Zn–CaP-coated Ti–6Al–7Nb alloy with controllable biodegradation as prepared by RFMS is a prospective material suitable for bone applications in cases where there is a risk of bacterial contamination with severe consequences, for example, in leukemic patients. Further research is needed to closely investigate the mechanical features and pathways of their solubility and antimicrobial, antitumor, and osteogenic activities.
机译：目前正在世界各地研究Ti-6AL-7NB，例如Ti-6AL-7NB的新型合金，作为其他Ti合金的替代物，例如Ti合金。而不是Ti-6al-4V。我们进行了一项试验研究，其中通过Ti-6al的射频磁控溅射（RFMS）射频磁控溅射（RFMS）制备了含有低剂量Zn2（0.4-0.8重量％）的薄（约1.2微米）的帽涂层。 -4V和Ti-6AL-7NB基质和研究其物理化学性质，体外溶解度，细胞毒性和抗菌和溶菌性活性。所得涂层的厚度约为1.2-1.3微米。 Zn取代不会导致无定形帽涂层中的粗糙度或结构或表面变化。如本元素的EDX映射所示，Ca，P和Zn的分布在膜厚度上均匀。 Zn掺杂帽涂层两种类型的Ti基合金统计学影响划痕试验的结果。然而，获得的值是令人满意的，可以在生物医学植入物上使用Zn-帽涂层。在0.9％NaCl溶液中的5周内，在0.9％NaCl溶液中的5周内发生Ca和磷酸盐离子的锥形输出增加。与Ti-6AL-4V不同，TI-6AL-7NB合金，在体外促进了更多线性生物降解的帽涂层。结果，与Ti-6AL-7NB的基于帽的表面，与Ti-6Al-4V合金相比，在统计学上以21天的人脂肪衍生的间充质干细胞培养的茜素红染色的总面积增强显着的方式。此外，Zn-Cap涂层在体外培养48小时内统计学降低了白血病Jurkat T细胞存活。随着Zn帽表面的较高溶解度，当涂层的7天提取物中加入微生物培养时，在体外观察到葡萄球菌的含量较大（4-至5.5倍）。因此，RFMS制备的具有可控生物降解的Zn-Cap-涂覆的Ti-6Al-7NB合金是适用于骨应用的前瞻性材料，其中在白血病患者中具有严重后果的细菌污染的情况下。需要进一步研究，以密切研究其溶解度和抗微生物，抗肿瘤和成骨活性的机械特征和途径。

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