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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Copper oxide (CuO) and manganese oxide (MnO) nanoparticles induced biomass accumulation, antioxidants biosynthesis and abiotic elicitation of bioactive compounds in callus cultures of Ocimum basilicum (Thai basil)
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Copper oxide (CuO) and manganese oxide (MnO) nanoparticles induced biomass accumulation, antioxidants biosynthesis and abiotic elicitation of bioactive compounds in callus cultures of Ocimum basilicum (Thai basil)

机译：氧化铜（CUO）和氧化锰（MNO）纳米颗粒诱导生物质积累，抗氧化剂生物合成和生物活性化合物的生物活性化合物在愈伤组织培养物（泰国罗勒）

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Nano-elicitation is one among the prioritised strategies considered globally for sustainable and uniform production of industrially important medicinal compounds. Ocimum basilicum (Thai basil), a renowned medicinal species is a reservoir of commercially vital metabolites and proved for its health assuring effects in cancer, diabetes, microbial and cardiovascular diseases. However, its consumption and industrial demand raised intent to divert towards better alternates for ensuring sustainable production of medicinal compounds. Herein, we investigated the comparative potential of metal oxide [copper oxide (CuO) and manganese oxide (MnO)] nanoparticles to elicit the biosynthesis of bioactive metabolites and antioxidative capacity of O.basilicum callus cultures. Results showed that callus grown on MS media supplemented with 10?mg/L CuO-NPs resulted in the highest biomass accumulation (FW: 172.8?g/L, DW: 16.7?g/L), phenolic contents (TPC: 27.5?mg/g DW), and flavonoid contents (TFC: 9.1?mg/g DW) along with antioxidant activities (DPPH: 94%, ABTS: 881?μM TEAC, FRAP: 386?μM TEAC) compared with MnO-NPs and control. Likewise, the Superoxide dismutase (SOD: 1.28?nM/min/mg FW) and Peroxidase (POD: 0.48?nM/min/mg FW) activities were also recorded maximum in CuO-NPs elicited cultures than MnO-NPs and control. Moreover, the HPLC results showed that rosmarinic acid (11.4?mg/g DW), chicoric acid (16.6?mg/g DW), eugenol (0.21?mg/g DW) was found optimum in cultures at 10?mg/L CuO-NPs. Overall, it can be concluded that CuO nanoparticles can be effectively used as a elicitor for biosynthesis of metabolites in callus cultures of O. basilicum (Thai basil). The study is indeed a contribution to the field that will help decoding the mechanism of action of CuO NPs. However, further molecular investigations are needed to fully develop understanding about the metabolic potential of O. bascillicum and scalling up this protocol for bulkup production of bioactive compounds.
机译：纳米引出是全球化的优先策略中的一个，可持续和均匀地生产工业上重要的药用化合物。一个着名的药物（泰国罗勒），着名的药物是商业上重要代谢物的储层，并证明其在癌症，糖尿病，微生物和心血管疾病中的保证作用。然而，它的消费和工业需求提出了旨在转移到更好的交替以确保可持续生产的药物化合物。在此，我们研究了金属氧化物ε和氧化锰（MNO）]纳米颗粒的比较潜力，以引发生物活性代谢物的生物合成和O.Basilicum Callus培养物的抗氧化能力。结果表明，愈伤组织在补充有10〜Mg / L CuO-NPS的MS培养基上生长，导致最高的生物质积累（FW：172.8？G / L，DW：16.7？G / L），酚类内容物（TPC：27.5？Mg / g DW）和黄酮醇内容物（TFC：9.1×mg / g dw）以及抗氧化活性（DPPH：94％：881μm茶，FRAP：386?μmTeac）与MNO-NPS和控制相比。同样地，超氧化物歧化酶（SOD：1.28·nm / min / mg fw）和过氧化物酶（Pod：0.48·nm / min / mg fw）的活性也比mno-nps和对照组在Cuo-nps引发培养物中记录。此外，HPLC结果表明，罗马啶酸（11.4×Mg / g DW），氟苯甲酸（16.6μmg/ g dw），在10℃的培养物中最佳地发现丁烯醇（0.21μmg/ g dw） -NPS。总的来说，可以得出结论，CuO纳米颗粒可以有效地用作O. Basilicum（泰国罗勒）的愈伤组织培养物中代谢物的生物合成的引发器。这项研究确实是对该领域的贡献，这将有助于解码Cuo NPS的作用机制。然而，需要进一步的分子调查来充分发展关于O. Bascillicum的代谢潜力的理解，并培养该方案以进行生物活性化合物的膨胀生产。

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