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首页> 外文期刊>International Journal of Pharmaceutical Sciences and Research >BREAKTHROUGHS IN TRANSDERMAL NANOSTRUCTURED LIPID CARRIER DRUG DELIVERY SYSTEMS
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BREAKTHROUGHS IN TRANSDERMAL NANOSTRUCTURED LIPID CARRIER DRUG DELIVERY SYSTEMS

机译：透皮纳米结构脂质载体药物递送系统的突破

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The important barrier in transdermal drug delivery (TDD) is the Stratum corneum (SC), the outermost layer of the skin, which acts as an excellent protective physiological barrier. To boost the penetration or permeation of drugs through SC, several tactics have been used including passive and active methods of permeation or both in combination. This unwraps the opportunity to broaden the range of drugs that can be administered through the transdermal route, performed as alternatives to existing products, and overcomes the weaknesses of conventional routes. The Nanostructured Lipid Carriers (NLCs) seem to be excellent candidates over conventional drug delivery systems. NLCs are fastly growing and in increased demand from?pharmaceutical research groups globally since the last decade. After development of liposomes and Solid Lipid Nanoparticles (SLN), NLCs were introduced. NLC overcomes the limitations of SLN, like the limited drug loading capacity and drug expulsion during storage. NLCs receive a preferred choice of formulation in the cosmeceutical market and Pharmaceutical market as well. This review is an overview of the different permeation barriers in TDD, focusing on the Nanostructured lipid carriers, as a proof-of-concept of a successful development strategy, formulation additives, Formulation methods, Characterization parameters of NLC, along with till the date breakthroughs in developments of NLC more specifically in transdermal drug delivery systems.
机译：透皮药物递送（TDD）的重要屏障是地层Cyneum（SC），皮肤的最外层层，其作为优异的保护性生理屏障。为了通过SC提高药物的渗透或渗透，已经使用了几种策略，包括渗透和渗透的无源和活性方法。这使得拓宽可通过透皮路线施用的药物范围的机会作为现有产品的替代品进行，克服了传统路线的弱点。纳米结构脂质载体（NLC）似乎是常规药物递送系统的优异候选者。 NLCS速度增长，从去年十年以来，全球药物研究群体的需求增加。在研制脂质体和固体脂质纳米颗粒（SLN）之后，引入了NLC。 NLC克服了SLN的局限性，如储存期间有限的药物负载能力和药物排出。 NLCS也在化妆品市场和制药市场中获得首选的配方选择。本综述是TDD中的不同渗透屏障概述，专注于纳米结构脂质载体，作为成功的发展策略，配方添加剂，配方方法，NLC的表征参数的概念，以及直到日期突破在透皮药物递送系统中更具体地进行NLC的开发。

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