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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption
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Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption

机译：去除褪黑激素受体型1信号传导诱导血脂血症和小鼠的激素变化进行环境昼夜破碎

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Background:Melatonin is a hormone secreted by the pineal gland in a circadian rhythmic manner with peak synthesis at night. Melatonin signalling was suggested to play a critical role in metabolism during the circadian disruption.Methods:Melatonin-proficient (C3H-f +/+ or WT) and melatonin receptor type 1 knockout (MT 1 KO) male and female mice were phase-advanced (6?hours) once a week for 6?weeks. Every week, we measured weight, food intake and basal glucose levels. At the end of the experiment, we sacrificed the animals and measured the blood's plasma for lipids profile (total lipids, phospholipids, triglycerides and total cholesterol), metabolic hormones profiles (ghrelin, leptin, insulin, glucagon, glucagon-like-peptide and resistin) and the body composition.Results:Environmental circadian disruption (ECD) did not produce any significant effects in C3H-f +/+ , while it increased lipids profile in MT 1 KO with the significant increase observed in total lipids and triglycerides. For metabolic hormones profile, ECD decreased plasma ghrelin and increased plasma insulin in MT 1 KO females. Under control condition, MT 1 KO females have significantly different body weight, fat mass, total lipids and total cholesterol than the control C3H-f +/+ females.Conclusion:Our data show that melatonin-proficient mice are not affected by ECD. When the MT 1 receptors are removed, ECD induced dyslipidaemia in males and females with females experiencing the most adverse effect. Overall, our data demonstrate that MT 1 signalling is an essential modulator of lipid and metabolic homeostasis during ECD.? 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
机译：背景：褪黑激素是昼夜节律方式的松果腺分泌的激素，夜间峰值合成。建议在昼夜破坏期间在新陈代表中发挥褪黑激素信号传导。方法：褪黑素 - 精通（C3H-F + / +或WT）和褪黑素受体1型敲除（MT 1 KO）雄性和雌性小鼠是相位的（6？小时）每周一次6？周。每周，我们测量重量，食物摄入和基底血糖水平。在实验结束时，我们牺牲了动物并测量了血液曲线的血液血浆（总脂质，磷脂，甘油三酯和总胆固醇），代谢激素谱（Ghrelin，Leptin，胰岛素，胰高血糖素，胰高血糖素样肽和抗胰蛋白酶）和身体成分。结果：环境昼夜性昼夜破坏（ECD）在C3H-F + / +中没有产生任何显着效果，同时它增加了MT 1 KO中的脂质曲线，在总脂质和甘油三酯中观察到的显着增加。对于代谢激素谱，ECD降低了血浆Ghrelin和Mt 1 Ko女性中的血浆胰岛素增加。在控制条件下，MT 1 KO女性具有显着不同的体重，脂肪量，总脂质和总胆固醇，而不是对照C3H-F + / + / +雌性。结论：我们的数据表明褪黑激素精度小鼠不受ECD的影响。当除去MT 1受体时，ECD在雄性和女性中诱导血脂血症的血脂，女性经历最不良影响。总的来说，我们的数据表明，MT 1信令是ECD期间脂质和代谢稳态的必要调节剂。 2020作者。 John Wiley＆Sons Ltd.出版的内分泌，糖尿病和新陈代谢

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