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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Effect of metformin on the high-density lipoprotein proteome in youth with type 1 diabetes
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Effect of metformin on the high-density lipoprotein proteome in youth with type 1 diabetes

机译：二甲双胍对1型糖尿病青年高密度脂蛋白蛋白质的影响

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Background Youth with type 1 diabetes (T1D) have normal or elevated High-Density Lipoprotein Cholesterol (HDL-C), however, the function of HDL, partly mediated by the HDL proteome, may be impaired. Metformin can be used as an adjunct therapy in youth with T1D, but its effects on the HDL proteome are unknown. Objective To determine the effect of metformin on the HDL proteome. Subjects Youth (12–20?years old) with T1D who had a BMI??90th percentile, HbA1c??8.0% and Tanner stage 5. Methods Double-blinded, placebo-controlled randomized sub-study. We examined the effects of metformin ( n =?25) or placebo ( n =?10) after 6?months on HDL proteome. Changes in HDL proteins were measured by data-independent acquisition (DIA) mass spectrometry and compared between treatment groups. As a secondary outcome, associations between proteins of interest and the most studied function of HDL, the cholesterol efflux capacity (CEC), was examined. Results The relative abundance of 84 HDL-associated proteins were measured. Two proteins were significantly affected by metformin treatment, peptidoglycan recognition protein 2 (PGRP2; +23.4%, p =?.0058) and alpha-2-macroglobulin (A2MG; +29.8%, p =?.049). Metformin did not significantly affect CEC. Changes in affected HDL proteins did not correlate with CEC. Conclusions Despite having little effect on HDL-C, metformin increased PGRP2 and A2MG protein on HDL in youth with T1D, but had no significant effect on CEC. Further studies are needed to understand the impact of PGRP2 and A2MG on other HDL functions.
机译：背景技术与1型糖尿病（T1D）具有正常或升高的高密度脂蛋白胆固醇（HDL-C），然而，可以损害由HDL蛋白质介导的HDL的功能。二甲双胍可以用作青少年的辅助治疗T1D，但其对HDL蛋白质组的影响是未知的。目的探讨二甲双胍对HDL蛋白质组的影响。主题青年（12-20？岁月）与T1D有BMI？＆？第90百分位数，HBA1c？＆？8.0％和Tanner Stage 5.方法双盲，安慰剂控制随机分布。在HDL蛋白质组上检查了6-个月后二甲双胍（n = 25）或安慰剂（n = 10）的影响。通过独立于数据无关的采集（DIA）质谱法测量HDL蛋白的变化，并在治疗组之间进行比较。作为次要结果，研究了感兴趣的蛋白质与HDL最多研究的函数，胆固醇流出能力（CEC）之间的关联。结果测量了84个HDL相关蛋白的相对丰度。通过二甲双胍治疗，肽聚糖识别蛋白2（PGRP2; + 23.4％，P =α.0058）和α-2-丙蛋白（A2mg; + 29.8％，P =β.049）受到显着影响两种蛋白质。二甲双胍没有显着影响CEC。受影响的HDL蛋白的变化与CEC无关。结论尽管对HDL-C，二甲双胍的影响几乎没有作用于青少年的HDL-C，但T1D的HDL蛋白质，但对CEC没有显着影响。需要进一步的研究来了解PGRP2和A2MG对其他HDL功能的影响。

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