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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Adiponectin, ALT and family history as critical markers for the development of type 2 diabetes in obese Japanese children
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Adiponectin, ALT and family history as critical markers for the development of type 2 diabetes in obese Japanese children

机译：Adiponectin，Alt和家族史作为肥胖日本儿童开发2型糖尿病的关键标志

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Aims/Introduction An association between the pathogenesis of type 2 diabetes mellitus (T2D) and that of metabolic syndrome (MS) in obese children has been suggested. We clarified the critical markers for the development of T2D in obese Japanese children. Methods One hundred and seven obese children who visited our outpatient clinic were enrolled in this study. The obese subjects were divided into 3 groups: Group A, T2D (n?=?19); Group B, MS but not T2D (n?=?19); and Group C: non‐T2D, non‐MS (n?=?69). In all the subjects, a biochemical examination was performed and the serum adiponectin and leptin levels were measured. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured using computed tomography images. Results Group A tended to have higher VAT values and VAT/SAT ratios and lower leptin and adiponectin levels, compared with Groups B and C. In Group A, the alanine aminotransferase (ALT) level was significantly higher and the aspartate aminotransferase (AST)/ALT ratio was significantly lower than in Group C. A receiver operating characteristic (ROC) analysis showed that the optimal cut‐off point for adiponectin was 6.4?μg/mL (AUC?=?0.859). The cut‐off points for ALT, the AST/ALT ratio and VAT were 35?IU/L (AUC?=?0.821), 0.85 (AUC?=?0.794) and 78?cm 2 (AUC?=?0.713), respectively. Group A had a significantly higher frequency of a family history of T2D than Group B. Conclusions Our study revealed that the adiponectin level, ALT level, AST/ALT ratio, VAT value and a family history of T2D may be critical characteristic markers for T2D among obese Japanese children.
机译：提出了AIMS /引入2型糖尿病（T2D）的发病机制与肥胖儿童代谢综合征（MS）之间的关联。我们澄清了肥胖日本儿童T2D发展的关键标志。方法参观了一百七十七种肥胖的儿童，他们参加了本研究。将肥胖受试者分为3组：A组，T2D（n？=？19）; B组，MS但不是T2D（n？=？19）;和C组：非T2D，非MS（n？=？69）。在所有受试者中，进行生化检查，测量血清脂联素和瘦蛋白水平。使用计算机断层摄影图像测量内脏脂肪组织（VAT）和皮下脂肪组织（饱现）。结果组A倾向于具有较高的增值税和vat / sat比和下瘦蛋白和脂肪蛋白水平，与B组和C组相比。在A组中，丙氨酸氨基转移酶（ALT）水平显着高，并且天冬氨酸氨基转移酶（AST）/ Alt比显着低于C组。接收器操作特征（ROC）分析表明，脂联素的最佳截止点为6.4Ω·μg/ mL（AUC？= 0.859）。 Alt的截止点，AST / ALT比和VAT为35？IU / L（AUC？= 0.821），0.85（AUC？= 0.794）和78？CM 2（AUC？=？0.713），分别。 A组的T2D家族历史频率明显高于B组。结论我们的研究表明，脂联素水平，ALT水平，AST / ALT比率，增值税值和T2D的家族历史可能是T2D中的关键特征标记肥胖日本儿童。

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