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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Hyperglycaemia increases mortality risk in non-diabetic patients with COVID-19 even more than in diabetic patients
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Hyperglycaemia increases mortality risk in non-diabetic patients with COVID-19 even more than in diabetic patients

机译：高血糖血症增加了非糖尿病患者的死亡风险，甚至超过糖尿病患者

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Aim Diabetes has been identified as a risk factor for poor outcomes in patients with COVID-19. We examined the association of hyperglycaemia, both in the presence and absence of pre-existing diabetes, with severity and outcomes in COVID-19 patients. Methods Data from 74,148 COVID-19-positive inpatients with at least one recorded glucose measurement during their inpatient episode were analysed for presence of pre-existing diabetes diagnosis and any glucose values in the hyperglycaemic range (180?mg/dl). Results Among patients with and without a pre-existing diabetes diagnosis on admission, mortality was substantially higher in the presence of high glucose measurements versus all measurements in the normal range (70–180?mg/dl) in both groups (non-diabetics: 21.7% vs. 3.3%; diabetics 14.4% vs. 4.3%). When adjusting for patient age, BMI, severity on admission and oxygen saturation on admission, this increased risk of mortality persisted and varied by diabetes diagnosis. Among patients with a pre-existing diabetes diagnosis, any hyperglycaemic value during the episode was associated with a substantial increase in the odds of mortality (OR: 1.77, 95% CI: 1.52–2.07); among patients without a pre-existing diabetes diagnosis, this risk nearly doubled (OR: 3.07, 95% CI: 2.79–3.37). Conclusion This retrospective analysis identified hyperglycaemia in COVID-19 patients as an independent risk factor for mortality after adjusting for the presence of diabetes and other known risk factors. This indicates that the extent of glucose control could serve as a mechanism for modifying the risk of COVID-19?morality in the inpatient environment.
机译：AIM糖尿病已被鉴定为Covid-19患者患者差的危险因素。我们检查了高血糖血症的关联，在存在和缺乏预先存在的糖尿病，在Covid-19患者中具有严重程度和结果。方法分析来自74,148个Covid-19阳性住院患者的数据，在其住院病程度发作期间具有至少一种记录的葡萄糖测量，用于存在预先存在的糖尿病诊断和血液血糖范围内的任何葡萄糖值（＆ 180×mg / dl）。结果在患有预先存在的糖尿病诊断的患者中，在两组中的正常范围（70-180×mg / dl）的所有测量中，死亡率在存在高葡萄糖测量的情况下基本上更高（非糖尿病： 21.7％与3.3％;糖尿病患者14.4％vs.3％）。在调整患者年龄，BMI，入院时的入院和氧饱和度的严重程度时，这种死亡率的风险增加持续存在，并且糖尿病诊断变化。在患有预先存在的糖尿病诊断的患者中，发作期间的任何高血糖价值都与死亡率的几率增加有关（或：1.77,95％CI：1.52-2.07）;在没有预先存在的糖尿病诊断的患者中，这种风险几乎翻了一番（或：3.07,95％CI：2.79-3.37）。结论这种回顾性分析鉴定了Covid-19患者的高血糖症，作为调整糖尿病和其他已知风险因素的死亡率的独立危险因素。这表明葡萄糖控制的程度可以作为改变Covid-19风险的机制？住院环境中的道德。

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