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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Type 2 diabetes in South Asians compared to Europeans: Higher risk and earlier development of major cardiovascular events irrespective of the presence and degree of retinopathy. Results from The HinDu The Hague Diabetes Study
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Type 2 diabetes in South Asians compared to Europeans: Higher risk and earlier development of major cardiovascular events irrespective of the presence and degree of retinopathy. Results from The HinDu The Hague Diabetes Study

机译：与欧洲人相比，南亚中的2型糖尿病：主要心血管事件的风险较高，而且无论视网膜病变程度如何。 印度教海牙糖尿病研究结果

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Introduction South Asians with diabetes have more severe diabetic retinopathy (DR) and cardiovascular complications than white Caucasians. However, how big this gap is and the relation with the severity of DR has not been studied. Here, we quantify the difference in time from diabetes diagnosis until a first non-fatal Major Adverse Cardiovascular Event (TUF MACE) in different DR groups in South Asians and Europeans. Methods 3831 adults with type 2 diabetes, 1358 South Asians and 2473 Europeans, treated in our diabetes clinic between 2006 and 2017 were included. Data on risk factors, diabetes duration, age of diagnosis and diabetes complications were collected from the diabetes-specific database and analysed using descriptive statistics and Cox regression. DR was graded in 3 categories, and non-fatal MACE was pre-specified. Results Prevalence of non-fatal MACE was the same when DR was absent, increased with increasing severity of DR in both ethnic groups, but was more frequent in South Asians with DR (mild: 50 vs. 42% and severe 62 vs. 46%. Classic risk factors only differed in relation to smoking habits, which were significantly lower in South Asians. After correction for classic risk factors and age at diabetes diagnosis TUF MACE was significantly shorter in South Asians, an effect also seen in the no-DR group (4.1?yrs. HR 1.5, 95% CI 1.3–1.8 and 7.4?yrs. earlier, HR 2.0, 95% CI 1.6–2.6 for no-DR and severe DR, respectively). Conclusions When adjusted for age at diabetes diagnosis, we show that time until first non-fatal MACE in South Asians is significantly shorter compared to Europeans and increases from no- to severe DR.
机译：引言南亚斯患有糖尿病的糖尿病患者具有更严重的糖尿病视网膜病（DR）和心血管并发症，而不是白色高加索人。然而，这个差距是多大的，并且没有研究与DR的严重程度的关系。在这里，我们量化糖尿病诊断的时间差异，直到南亚和欧洲不同博士群体的第一个非致命主要不良心血管事件（TUF MACE）。方法包括2831例患有2型糖尿病，1358名南亚和2473名欧洲人的成人，在2006年至2017年间在我们的糖尿病诊所治疗。关于危险因素，糖尿病持续时间，诊断年龄和糖尿病并发症的数据被从糖尿病特异性数据库中收集，并使用描述性统计和COX回归分析。 DR分为3个类别，预先指定了非致命钉。结果在博士缺席时，非致命均匀的患病率相同，随着劳动博士的严重程度增加，但在南亚与博士中更频繁（温和：50与42％和严重62 vs.46％ 。经典风险因素与南亚南亚的烟熏习惯有关。南亚经典风险因素和年龄矫正后南亚人群较短，在南亚人群中较短，在NO-DR组中也看到了一项效果。 （4.1？YRS。HR 1.5,95％CI 1.3-1.8和7.4？YRS。早期，HR 2.0,95％CI 1.6-2.6分别用于NO-DR和严重DR）。结论在糖尿病诊断时调整为年龄，我们展示了与欧洲人相比，南亚中第一个非致命迈克的时间明显缩短，并且从不恢复博士增加。

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